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水杨酸盐体外抑制铜绿假单胞菌外膜蛋白OprD_2的表达 被引量：3

Sodium Salicylates Depress the Synthesis of OprD_2 in Pseudomonas aeruginosa in vitro
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摘要 目的　探讨水杨酸盐对铜绿假单胞菌碳青酶烯类抗生素耐药机制的影响。方法　以亚胺培南为代表 ,分析不同浓度的水杨酸盐 ,对 10株临床分离的铜绿假单胞菌体外抗菌活性、Opr D2 相对含量的影响。结果　随着水杨酸盐浓度的增高 ,亚胺培南体外抗菌活性逐渐下降 ,Opr D2 的相对含量逐渐减少。结论　水杨酸盐能抑制铜绿假单胞菌 Opr D2 的表达 。 OBJECTIVE To investigate the influence of sodium salicylates on the mechanism of carbapenems resistance in Pseudomonas aeruginosa. METHODS To analyze the relationship between different concentration of sodium salicylates and antibacterial activity of imipenem in vitro, relative amounts of OprD 2 in 10 isolates. RESULTS With the elevation of inducible concentration of sodium salicylates, the antibacterial activity of imipenem in vitro dropped gradually, the relative amounts of OprD 2 decreased too. CONCLUSIONS Sodium salicylates depress the synthesis of OprD 2 in P. aeruginosa to induce the resistance to carbapenems.
作者 陈瑞 唐英春 朱家馨 吴本权 谈淑卿
机构地区 中山大学附属第二医院 中山大学附属第三医院
出处 《中华医院感染学杂志》 CAS CSCD 2004年第11期1204-1206,共3页 Chinese Journal of Nosocomiology
基金 广东省科技厅科研基金重点资助项目(编号 :A2 4 2 )
关键词 外膜蛋白 铜绿假单胞菌 亚胺培南 耐药性 Outer membrane protein Pseudomonas aeruginosa Imipenem Resistance
分类号 R378.991 [医药卫生—病原生物学]
  • 相关文献

参考文献8

  • 1陈 瑞,唐英春,朱家馨,吴本权,谈淑卿.铜绿假单胞菌对碳青霉烯类抗生素的耐药机制——耐药株外膜蛋白OprD_2缺失[J].中国抗感染化疗杂志,2001,1(4):229-230. 被引量：52
  • 2[2]Sawai T, Hirano S, Yamaguchi A. Repression of porin synthesis by salicylates in Escherichia Coli, Klebsiella pneumoniae and Serratia marcescens[J]. FEMs Microbiol Lett, 1987, 40(1): 233-237.
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二级参考文献8

  • 1Murthy SK, Balch AL, Smith RP, etal. Oropharyngeal and fecal carriage of Pseudomonas aeruginosa in hospital patients[J]. JClin Microbiol, 1989, 27(1):35-40
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共引文献51

同被引文献27

  • 1Lynch M J, Drusano GL, Mobley HL. Emergence of resistance to imipenem in Pseudomonas aeruginosa[ J]. Antimicrob Agents Chemother, 1987,31 (12) : 1892-1896.
  • 2Yoshihara E, Nakae T. Identification of porins in the outer membrane of Pesudomonas aeruginosa that form small diffusion pores[ J]. J Biol Chem, 1989, 264 ( 11 ) :6297-6301.
  • 3Ochs MM, McCusker MP, Bains M, et al. Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids [ J ]. Antimicrob Agents Chemother, 1999,43 (5) : 1085-1090.
  • 4Watanabe M, Iyobe S, Inoue M, et al. Transferable imipenem resistance in Pseudomonas aeruginosa [J]. Antimicrob Agents Chemother, 1991,35 ( 1 ) :147-151.
  • 5Strateva T, Ouzounova-Raykova V, Markova B, et al. Widespread detection of VEB-1-type extended-spectrum β-lactamases among nosocomial ceftazidime-resistant Pseudomonas aeruginosa isolates in Sofia, Bulgaria[J]. J Chemother,2007,19(2) :140-145.
  • 6Johann D, Pitout D, Gregson DB, et al. Detection of pseud om onas aeruginosa producing metallo β lactamases in a large centralized laboratory. J Clin Microbiol, 2005, 43(7):3129- 3135.
  • 7衣美英,刘迎春,王鹏远,刘玉村.耐亚胺培南铜绿假单胞菌外膜孔蛋白与β-内酰胺酶研究[J].中华医院感染学杂志,2007,17(10):1198-1200. 被引量：23
  • 8Yoshihara E, Nakae T. Identification of porins in the outer membrane of Pseudomonas aeruginosa that form small diffu- sion pores[J]. J Biol Chen, 1989,264(11) =6297-6301.
  • 9Sumita Y, Fukasawa M. Traisient carbapenem resistance induced by salicylate in Pseudomonas aeruginosa associat- ed with suppression of out menbrane protinD2 synthesis[J]. Antimicrob Agents Chemother, 1993,37 (12): 2743- 2746.
  • 10Li H, Luo YF, Williams BJ, et al. Structure and function of OprD protein in Pseudomonas aeruginosa: from antibiotic resistance to novel therapies[J]. Int J Med Microbiol, 2012,302(2) :63-68.

引证文献3

二级引证文献19

中华医院感染学杂志
2004年 第11期

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