摘要
目的 了解VEGFmRNA在大鼠视网膜缺血再灌注损伤中的表达及意义。方法 建立大鼠视网膜缺血再灌注模型 ,以原位杂交法检测VEGFmRNA在大鼠视网膜中的表达 ,进行统计学处理。结果 VEGFmRNA大鼠视网膜缺血再灌注 12小时开始表达 ,第 48小时达到最高 ,以后逐渐减弱。结论 VEGFmRNA在大鼠视网膜缺血再注灌注损伤中起重要作用。
Objective To study VEGF expression in rat's re tina which injuried by ischemia-reperfusion.Methods The model of rat's retina ischemia-reperfusion was made ,used ISH method to test the VEGFmRNA expression in rat's retina.Results At one hour after ischemia-reperfusion,there was no VEG FmRNA expression in rat's retina,after 12 hours of ischemia-reperfusion,there wa s some VEGFmRNA expressed in retina and reached the hightest level at 48 hours a fter ischemia-reperfusion.Then it began to decrease,but there was VEGFmRNA expre ssion in retina after 72 hours.Conclusion VEGF is very important in rat's retina ischemia-repe rfusion injury.
出处
《眼外伤职业眼病杂志》
北大核心
2004年第11期721-723,共3页
Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries
