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猴病毒40与人脑胶质瘤发生关系的研究

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摘要 人脑胶质瘤是中枢神经系统最常见的恶性肿瘤,其病因和发病机理尚未明了。作为肿瘤病毒,猴病毒40(SV40)的动物致癌性已经明确,近年来,有关SV40感染与人类肿瘤关系的研究较多,尽管与胶质瘤关系的研究较为分散,但研究已表明SV40潜在性的感染所诱导的细胞转化功能,参与了人脑胶质瘤的某些发生过程,在胶质瘤形成过程中起重要作用,由SV40引起的P53等抑癌基因失活被认为是SV40相关性胶质瘤发生的一个重要分子机理。
出处 《国外医学(神经病学.神经外科学分册)》 2004年第5期436-438,共3页 Foreign Medical Sciences(Section On Neurology & Neurosurgery)
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