摘要
目的 探讨阿魏酸钠对介入治疗 (PCI)后血管内皮功能的影响及干预作用。方法 对 6 0例成功行PCI后的冠心病患者在常规治疗 (阿托伐他汀、阿斯匹林、ACEI、硝酸酯类 )的基础上按分层随机分配法分为阿魏酸钠组 (n =30例 )和对照组 (n=30例 )。全部病例采用高分辨超声技术 ,分别在PCI后 3天、18天检测肱动脉舒张功能 :反应性充血后血管舒张 (FMD)、含服硝酸甘油后的血管舒张 (NID) ,且同步检验血内皮素 (ET)、一氧化氮 (NO)等指标并进行对比分析。结果 (1)两组干预后的FMD、NO均较干预前显著升高 (均P <0 0 1或P <0 0 5 ) ,ET则降低 (均P <0 0 1或P <0 0 5 ) ;(2 )干预后 :阿魏酸钠组的FMD、NO均较对照组显著升高 (均P <0 0 5 ) ,ET则降低 (P <0 0 5 ) ;(3)NID在各组干预前后、组间比较均无差异 (P <0 0 5 )。结论 应用国产阿托伐他汀能改善PCI后血管内皮功能 ;阿魏酸钠可进一步改善PCI后血管内皮功能。
Objective To investigate the interference of sodium ferulate in endothelium function after percutaneous coronary intervention (PCI) in accordance with Stochastic Variable method.Methods Under the conditions of routine therapy (by taking atovastatin, aspirin ,ACEI and nitroglycerin), 60 successful post-PCI cases were divided into Test Group (n=30) treated by sodium ferulate and Control Group (n=30). High-resolution ultrasound technique was applied for all the cases involved to determine the brachial artery vasodilation, brachial artery flow mediated vasodilation (FMD) and nitroglycerin-induced vasodilation (NID) in 3 and 18 days after PCI. In the meantime, the plasma levels of endothelium (ET) and nitric oxide (NO) were also tested. All the indexes were compared and analyzed.Results (1) Either FMD or NO had significantly increased compared to those before interference (all P<0.01 or P<0.05), while ET had dropped (all P<0.01 or P<0.05); (2) After interference, FMD and NO in Test Group had significantly increased (P<0.05) , whereas, ET level had obviously dropped (P<0.05); Before and after interference, NID values inside the group and between the groups showed no significant difference (P>0.05).Conclusion The artery endothelium function after PCI can be improved by admitting domestically manufactured atovastatin and the sodium ferulate can further improve the artery endothelium function.
出处
《广西医学》
CAS
2004年第10期1418-1421,共4页
Guangxi Medical Journal
基金
广西自然科学基金资助项目 (桂科基 0 15 6 0 2 3)
