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CD40-CD40L在动脉粥样硬化及急性冠状动脉综合征的研究进展 被引量：1

Research Progress of CD40CD40L in Atherosclerosis and Acute Coronary Syndrome
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摘要 近年研究表明冠心病是免疫参与的慢性炎症反应。免疫介质CD40及其配体广泛存在于T、B淋巴细胞、内皮细胞、平滑肌细胞、单核 /巨噬细胞、血小板及上皮细胞表面 ,二者相互作用可诱导上述细胞产生许多致炎因子 ,参与动脉粥样硬化的发生、发展及转归。阻断CD40 CD40L的相互作用可以抑制动脉粥样硬化 (AS)的发生与发展 ,为防治动脉粥样硬化和急性冠状动脉综合征 (ACS)提供新的治疗手段。
作者 李永旺 曲鹏
机构地区 大连市中心医院心内 大连医科大学附属二院心内科
出处 《心血管病学进展》 CAS 2004年第6期473-476,共4页 Advances in Cardiovascular Diseases
关键词 动脉粥样硬化(AS) CD40-CD40L 急性冠状动脉综合征 单核 免疫介质 治疗手段 慢性炎症 细胞 相互作用 致炎因子
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献36

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同被引文献8

  • 1Hansson GK. Inflammation atherasclevosis and comnmy artery disease[J].N Engl Med, 2005, 352 C2) : 1 685 - 695.
  • 2Tombal B, Weeraratna AT, Denmeade SR, et al. Thapsigargin induces a calmodulin/calcineurin dependent apoptotic cascade responsible for the death of prostatic Cancer cells [J]. Prostate, 2000, 43 (4) : 303-317.
  • 3Antonino B, Luigi B, Giovanna L, et al. Widespread coronary inflammafion in unstable angina [ J ]. N Engl Med, 2002, 347 (1) : 5-12.
  • 4Wal AC, Becker AE, Loos CM, et al. Site of intimal rapture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an imqamma- tory process irrespective of the dominant plaque morphology [ J ]. C/rcu/a- tion, 1994, 89 (1): 36-44.
  • 5Danilo G. Calcineurin, not just a simple protein phosphatase [ J ]. Biochem Biophys Res Commun, 1997, 235 (2) : 271-275.
  • 6Valerie B, Abbott KL, Wang XF, et al. The cyelosporine A--sensitive nuclear factor of activated T cells(NFAT) proteins are expressed in vascular smooth muscle cells. Differerttial localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell surface reeeptors [ J]. Biol Chem, 1998, 273 (31): 19 664-671.
  • 7Uwe Schtlnbeck, Peter L. CD40 signaling and plaque instability [J]. CircRes, 2001, 89 (12): 1 092-103.
  • 8李映红,欧阳静萍,魏劲波.钙调神经磷酸酶在心血管系统中的作用[J].中国动脉硬化杂志,2003,11(5):477-480. 被引量：14

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心血管病学进展
2004年 第6期

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