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NF-κB及其相关分子在炎症性疾病中作用的探讨 被引量：3

Nuclear Factor-kappa B(NF-κB ) and Associated Molecules with Inflammatory Diseases
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摘要 细胞在静息状态下 ,NFκB与一组抑制蛋白IκB家族成员结合而存在于细胞质中 .在诱导因子刺激下 ,IκB磷酸化、泛素化 ,随后被蛋白水解酶体降解 ,释放NFκB ,使之进入细胞核结合DNA ,调节多种基因的表达 .NFκB在免疫系统和炎症性疾病中发挥着重要的调节作用 . In un-stimulated cells, transcription factor NF-κB is kept in cytoplasm through interaction with IκB inhibitory proteins. Exposure to inducers stimuli results in IκB phosphorylation and ubiquitilation. Liberated NF-κB is trans-located to the nucleus and bind to DNA, where they regulate the expression of a wide variety of genes. Recent studies have indicated that the NF-κB plays a central role in the regulation of inflammatory diseases and the study of the regulation of NF-κB pathways will provide a platform for developing specific therapy for inflammatory diseases.
作者 蒋培余
机构地区 湖州师范学院医学院
出处 《湖州师范学院学报》 2004年第2期98-101,共4页 Journal of Huzhou University
关键词 NF-κB/Rel蛋白家族 IκB家族 IΚB激酶 炎症性疾病 NF-κB/Rel family IκBs family IκB kinase inflammatory diseases
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献10

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二级参考文献24

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湖州师范学院学报
2004年 第2期

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