摘要
目的 :探讨慢性心力衰竭患者血清胰岛素样生长因子 -Ⅱ (IGF -Ⅱ )变化及其临床意义。方法 :用放射免疫分析测定了 132例慢性心力衰竭 (CHF)患者和 4 5例非慢性心力衰竭患者的血清IGF -Ⅱ水平 ,并进行对照统计分析。结果 :CHF组血清IGF -Ⅱ水平显著高于对照组 (P <0 0 0 1)。在Ⅱ、Ⅲ、Ⅳ级组间 ,血清IGF -Ⅱ水平依次递增 (方差F检验 ,P <0 0 1) ,且Ⅳ级组显著高于Ⅱ级组和Ⅲ级组 (P <0 0 1)。住院期间死亡组血清IGF -Ⅱ水平显著高于好转出院组 (P <0 0 1)。结论 :CHF患者血清IGF -Ⅱ水平显著升高 ,Ⅳ级组血清IGF -Ⅱ显著高于Ⅱ级组和Ⅲ级组 ,住院期间死亡组血清IGF -Ⅱ水平也显著高。
Objective To investigate the clinical significance of changes of seurm insulin-like growth factor Ⅱ (IGF-Ⅱ) levels in patients with chronic heart failure. Methods Serum IGF-Ⅱ levels were measured with RIA in 132 cases of chronic heart failure and 45 controls. Results Serum IGF-Ⅱ levels were significantly higher in patients with chronic heart failure than those in the controls (t=0.033, P<0.001). IGF-Ⅱ levels were highest in grade Ⅳ CHF patients (vs grade Ⅱ t=3.963, P<0.01; vs grade Ⅲ, t=3.578, P<0.01). In the twelve patients died in hospital, the serum IGF-Ⅱ levels were significantly higher than those patients recovered (t=7.141, P<0.01). Conclusion Serum IGF-Ⅱ levels were increased in CHF patients and were highest in the most severe cases.
出处
《放射免疫学杂志》
CAS
2004年第5期341-343,共3页
Journal of Radioimmanology
