期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

趋化因子CCL28及其受体CCR10的分子生物学 被引量：2

Molecular Biological Characterization of Chemokine CCL28 and Its Receptor CCR10
暂未订购
导出
摘要 CCL2 8是趋化因子CC家族成员 ,其受体为CCR10和CCR3。CCL2 8与CC家族其他成员有同源性 ,但是它在基因定位、蛋白质结构和表达调控上有其独特性 ,这决定了它不仅可以与CCR10结合诱导循环IgA浆母细胞的归巢和迁移 ,而且具有广谱的抗微生物活性。 CCL28, a member of chemokine CC subfamily, signal via CCR10 and CCR3. Although CCL28 is homologous to other chemokines in CC subfamily, it is unique in its gene position, protein structure and expression, which imparts to it the ability to induce homing and transference of circulating IgA screting cells, and the broad-spectrum antimicrobial activity.
作者 丁力 郭葆玉
机构地区 第二军医大学药学院生化药学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2004年第5期306-308,共3页 Journal of Medical Molecular Biology
关键词 趋化因子 受体 CCR 分子生物学 归巢 家族成员 CCL 表达调控 蛋白质结构 同源性 chemokines CCL28 CCR10
分类号 R392 [医药卫生—免疫学] R-332 [医药卫生]
  • 相关文献

参考文献18

  • 1Zabel BA, Agace WW, Campbell JJ, et al. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 Is selectively expressed on intestinal homing T lymphocytes,mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediate
  • 2Eric JK, James JC, Guttorm H, et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing p
  • 3Homey B, Wang W, Soto H, et al. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2(GPR-2, CCR10) binds the skin-associated chemokine CCL27 ( CTACK/ALP/ILC ). J Immunol, 2000, 164(7): 3 465-70.
  • 4Ishikawa MI, Kitaura M, Baba M, et al. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. F
  • 5Yoshie O, Imai T, Nomiyama H. Chemokines in immunity, Adv Immunol, 2001, 78: 57-110.
  • 6Hieshima K, Ohtani H, Shibano M, et al. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J Immunol, 2003, 170 (3):1 452-61.
  • 7Nakayama T, Hieshima K, Izawa D, et al. Cutting edge:profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. J Immunol, 2003, 170 (3): 1 136-40.
  • 8Lazarus NH, Kunkel EJ, Johnston B, et al. A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. J Immunol, 2003, 170 (7): 3 799-805.
  • 9Bowman EP, Kuklin NA, Youngman KR, et al. The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. J Exp Med, 2002,195: 269-75.
  • 10Eric JK, Chang HK, Nicole HL, et al. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest, 2003, 111:1 001-10.

同被引文献17

  • 1Olson TS, Ley K. Chemokines and chemokine receptors in leukocyte traffcking [ J ]. Am J Physiol Regulatory Integrative Comp Physiol, 2002, 283:7-28.
  • 2Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation[J]. N Engl J Me, 2006, 354: 610-621.
  • 3Wang W, Soto H, Oldham E R, et al. Identification of a novel chemokine CCK28, which binds CCR10 ( GPR2 ) [ J ]. J Biol Chem, 2000, 275(29):22313-22323.
  • 4Lazarus NH , Kunkel E J, Johnston B, et al. A common mucosal chemokine (mucosae- associated epithelial chemokine/CCL28 ) selectively attracts IgA plasmablasts[J]. J Immunol, 2003, 170 (7) :3799 -3805.
  • 5Wurbel, M. A. , Philippe J. M., Nguyen C. , et al . The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double - and single - positive thymocytes expressing the TECK receptor CCR 9[J]. EUR. Immunol , 2000, 30:262 - 271.
  • 6Meurens F, Berri M, Whale J, et al. Expression of TECK/ CCL25 and MEC/CCL28 chemokines and their respective receptors CCPO and CCR10 in porcine mucosal tissues[J]. Vet Immunol Immunopathol, 2006, 113(3 -4) :313 -327.
  • 7Pabst O, Ohl L, Wendland M, et al. Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine [J]. J Exp Med, 2004, 199(3) :411 -416.
  • 8Francois Meurens, Julia Whale, Robert Brownlie, et al. Expression of mucosal chemolines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune systen [J]. Immunology, 2006, 11(9):130 -135.
  • 9Olson TS, Ley K. Chemokines and chemokine receptors in leukocyte trafficking [ J ]. Am . J. Physiol. Regulatory Integrative Comp. Physiol. , 2005, 283:7-28.
  • 10Charo IF, Ransohoff RM. The many roles of ehemokines and chemokine receptors in inflammation[J]. J . Medecine, 2006, 354: 610 - 621.

引证文献2

医学分子生物学杂志
2004年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部