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IL-23的研究进展 被引量：6

Advances in the Study of IL-23
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摘要 IL 2 3是新近发现的一种细胞因子 ,主要来源于活化的单核巨噬细胞和B细胞。它具有多种生物学功能 ,能促进T细胞尤其是CD4 + T细胞增殖 ,促进T细胞、抗原提呈细胞产生IFN γ与IL 12 ,对树突状细胞的共刺激功能起调节作用 ,具有抗肿瘤和抗转移活性 ,而且与自身免疫和炎症反应疾病密切相关。 IL-23 is a recently discovered heterodimeric cytokine. It is mainly produced by activated macrophages and B cells. IL-23 has been shown to possess multiple biological activities. For example, it can enhance T cells especially CD4 + T cell proliferation and interferon-gamma, IL-12 production from T cells, myeloid antigen-presenting cells (APCs). It can also modulate the costimulatory function of dendritic cells (DC). Additionally, recent studies demonstrated that IL-23 has antitumor and antimetastatic activity, and it may also be involved in the development of autoimmune diseases and inflammatory diseases.
作者 徐玢 马小彤
机构地区 中国医学科学院中国协和医科大学血液学研究所
出处 《医学分子生物学杂志》 CAS CSCD 2004年第5期302-305,共4页 Journal of Medical Molecular Biology
关键词 IL-2 T细胞增殖 共刺激 抗原提呈细胞 IL-12 研究进展 自身免疫 生物学功能 发现 抗肿瘤 IL-23 IL-12 cytokine
分类号 R392 [医药卫生—免疫学] R730 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Verreck FA, de Boer T, Langerberg DM, et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc Natl Acad Sci USA, 2004, 101 (13): 4560-5.
  • 2Kopp T, Lenz P, Bello-Fernandez C, et al. IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: Evidence for enhanced cutaneous immunity. J Immunol, 2003, 170(11): 5438-44.
  • 3Elkins KL, Cooper A, Colombini SM, et al. In vivo clearance of an intracellular bacterium, Francisella tularensis LCS, is depandent on the p40 subunit of interlukin12 (IL-12) but not on IL-12p70. Infect Immun, 2002,70 (4): 1 936-48.
  • 4Oppmann B, Lesley R, Blom B, et al. Novel p19 protein Engsgrd IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 2000, 13 (5): 715-25.
  • 5Wang YQ, Ugai S, Shimozato O, et al. Induction of sysemic immunity by expression of interleukin-23 in murine colon carinoma cells. J Cancer, 2003, 105 (6): 820-4.
  • 6Shan B, Yu L, Shimozato O, et al. Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice. Anticancer Res, 2004, 24(1): 79-82.
  • 7Ha SJ, Kim DJ, Back KH, et al. IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol, 2004, 172 (1): 525-31.
  • 8Pirhonen J, Matikainen S, Julkunen I, et al. Regulation of virus-Induced IL-12 and IL-23 expression in humman macrophages. J Immunol, 2002, 169 (10): 5 673-78.
  • 9Wiekowski MT, Leach MW, Evans EW, et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, inferTility, and premature death. J Immunol, 2001, 166 (12): 7 563-70.
  • 10Lee E, Trepicchio WL, Oestreicher JL, et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med, 2004, 199(1): 125-30.

同被引文献54

  • 1杨道秋,姜岩峰.T细胞在银屑病发病中的作用的研究进展[J].实用医药杂志,2005,22(10):944-945. 被引量：2
  • 2潘玉芹,林文娟.细胞因子和抑郁症[J].心理科学进展,2006,14(6):901-906. 被引量：15
  • 3李国忠,王丹丹,王菁华,王广友,孙博,王德生,金连弘,李呼伦.人脑缺血组织中IL-17表达及来源[J].中风与神经疾病杂志,2006,23(6):662-665. 被引量：9
  • 4Ouyang W,Kolls JK,Zheng Y.The biological functions of T helper17 cell effector cytokines in inflammation[J].Immunity,2008,28(4):454-467.
  • 5Witowski J,Ksiazek K,J rres A.Interleukin17:a mediator of in flammatory responses[J].Cell Mol Life Sc,2004,61(5):567-579.
  • 6Higgins SC,Jarnicki AG,Lavelle EC,et al.TLR4mediates vaccine induced protective cellular immunity to Bordetella pertussis:role ofIL 17 producing T cells[J].J Immunol,2006,177(11):7980-7989.
  • 7Parham C,Chirica M,Timans J,et al.A receptor for the heterodi meric cytokine IL 23 is composed of IL 12Rbeta1 and a novel cyto kine receptor subunit,IL 23R[J].J Immunol,2002,168(11):5699-5708.
  • 8Khader SA,Bell GK,Pearl JE,et al.IL23and IL17in the estab lishment of rotective pulmonary CD4+T cell responses after vaccina tion and during mycobacterium tuberculosis challenge[J].Nat Immu nol,2007,8(4):369-77.
  • 9Rutitzky L,Bazzone L,Shainheit MG,et al.IL23is required for thedevelopment of severe egg induced immunopathology in schistosomia sis and for Lesional Expression of IL 17[J].J Immunol,2008,180(4):2486-2495.
  • 10Yoshio O,Shoichi S,Takashi K,et al.Schistosoma mansoni infec tion reduces severity of collagen induced arthritis via down regula tion of pro inflammatory mediators[J].Inte J Parasitol,2009,39,457-464.

引证文献6

二级引证文献47

医学分子生物学杂志
2004年 第5期

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