摘要
目的 探讨造成流产、胚停育、死胎、死产、不孕 (不育 )、生育畸形儿和智力低下儿的细胞遗传学原因。方法对我院 1987年 8月～ 2 0 0 3年 7月 715对有生殖异常的夫妇进行外周血G带染色体分析。结果染色体异常占受检人数的 7.4 1% ( 10 6 /14 30 )。其中 ,自然流产、胚停育、死胎、死产的夫妇 ,染色体异常占受检人数的 5 .84 % ( 5 4 /92 4 ) ;生育过畸形儿或智力低下儿的夫妇 ,染色体异常占受检人数的 4 .70 % ( 11/2 34) ;不孕 (不育 )的夫妇 ,染色体异常占受检人数的 15 .0 7% ( 4 1/2 72 )。结论生殖异常与染色体异常有密切的关系。
Objective: To study the relationship between chromosome aberrations and various reproductive conditions, including miscarriage,stillbirth,infertility,amenorrhoea and given birth to babies with congenital malformations and lower intelligence. Methods Frequencies of chromosome aberrations based on chromosome G-banding results for 715 genetic consultants to our institute from August 1987 to July 2003. Results Among the 1430 consultants 106 (7.41%) had chromosome aberrations and among 924 who have recurrent miscarriage, stillbirth, stopping of embryo development, 54 (5.84%) have chromosome aberrations. Among 234 who have given birth to babies with congenital malformations and lower intelligence, 11 (4.70%) have chromosome aberrations. Among 272 who are infertility, 41(15.07%) have chromosome aberrations. Conclusion Chromosome aberrations are associated with various reproductive problems.
出处
《中国优生与遗传杂志》
2004年第5期50-51,共2页
Chinese Journal of Birth Health & Heredity
