摘要
目的 探讨ERβ基因多态性在中国正常汉族人群中的分布特点及其与血脂水平的关系。方法 检测湖北地区 15 3例正常人的ERβ基因RsaI和AluI酶切多态性 ,同时检测血脂水平。结果 ERβ基因rr、RR基因型构成比为 0 .2 94和0 .15 0 ;aa、AA基因型构成比为 0 .76 5和 0 .0 13。RsaI及AluI不同基因型间血清TC、TG、HDL -C、LDL -C、ApoAI、ApoB水平均有一定差异 ,但无统计学意义 (P >0 .0 5 )。结论 不同地区人群间ERβ基因多态性的分布存在一定差异性。
Objective: In order to explore estrogen receptor β (ERβ) gene polymorphism in Chinese Han nationality and its relation with blood lipid level. Methods: 153 healthy people were studied. PCR-RFLP technique were employed to determine ERβ gene polymorphism. Results: The frequency distribution of rr, RR and aa, AA genotypes is 0.294, 0.150 and 0.765, 0.013 respectively. When the subjects were divided into 3 subgroups according to RsaI and AluI genotype, the differences of blood lipid level among the subgroups were not statistically significant (P>0.05). Conclusions: There were statistically significant differences in ERβ genotype frequencies in different region populations. ERβ RsaI and AluI gene polymorphism dose not have obvious influence on lipid metabolism.
出处
《中国优生与遗传杂志》
2004年第5期21-23,共3页
Chinese Journal of Birth Health & Heredity
基金
湖北省自然科学基金资助课题 批准号 :2 0 0 0J0 70
