摘要
目的 探讨米非司酮对中孕胎儿肝、肾、脑组织损伤的可能性。方法 采用免疫组化方法 ,检测 17例米非司酮中期引产胎儿肝、肾、脑组织DNA损伤基因Pur -α的表达。实验组按孕龄分为 :Ⅰ组 6例孕 12～ 15w ;Ⅱ组 8例孕 16～2 3w ;Ⅲ组 3例孕 2 4 - 2 8w。水囊引产胎儿 5例 ,设为对照组 ;结果 实验组 pur-α呈强阳性表达 ( P <0 .0 1)。对照组 pur -α均呈阴性表达。结论 中期妊娠使用米非司酮可造成胎儿肝、肾、脑组织的损伤。pur -α是检测基因损伤最敏感的指标之一。
Objective: Through the Analysis of the expression of Pur-αto explore the damaging effects in the fetal liver, kidney, and brain with the administration of mifepristone. Methods: Twenty-two specimens were obtained from women who volunteered to terminate their pregnancy between 12-28weeks. Seventeen specimens were obtained from women who took the mifepristone 75mg orally for 2 days (total dose 150 mg ) and 48 hours later misoprostol was given vaginally every 12 hours . According to the fetal gestational age, these specimens were divided into 3 test groups: groupⅠ(12～15weeks),group Ⅱ(16～23weeks), group Ⅲ(24～28weeks). Five specimens were obtained from the water bag abortion as the control group. Immunohistochemistery was induced to investigate the presence of Pur-α protein. The results were statistically analyzed. Results: The positive detections of pur-α in all test groups were significantly different from the control group (P<0.01). Conclusion: Pur-αis one of the most sensitive targets in detecting the damage of DNA. The application of mifepristone in medium-term pregnancy can result in damage of the fatal liver, kidney and brain.
出处
《中国优生与遗传杂志》
2004年第5期8-9,23,F003,共4页
Chinese Journal of Birth Health & Heredity
