摘要
目的 :研究柔性纳米脂质体对皮肤角质层结构的改变。方法 :将等渗磷酸盐缓冲液 (pH 7 4 )、柔性纳米脂质体、胆酸钠溶液分别应用于人离体皮肤角质层和小鼠在体皮肤表面 ,应用扫描电镜观察角质层的结构。结果 :离体条件下 ,柔性纳米脂质体处理过的人角质层 ,角质细胞间隙明显增宽。在体条件下 ,小鼠皮肤表面无显著性差异。结论 :离体条件下 ,柔性纳米脂质体在角质层中的转运可能以融合扩散为主 ,在体条件下以穿透机制为主 。
AIM:To discover the structure change of stratum corneum with flexible nanoliposome METHOD:Isotonic phosphate buffer(pH 7 4),flexible nanoliposome and sodium cholate solution were respectively applied to cadaver stratum corneum and the mice skin Scan electron microscopy was utilized to observe the structural change RESULT:Interstices were widened up after application of flexible nanoliposomes in vitro,but there was no significant change of skin structure in situ in mice CONCLUSION:The transport mechanism was probably fusion in vitro and penetration in situ
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2004年第5期406-408,共3页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助项目 (No 3 9770 881)~~
关键词
柔性纳米脂质体
皮肤
角质层
透皮吸收
Flexible nano-liposomes
Skin
Stratum corneum
Transdermal delivery
