3Brennan CW, Verhaak RG, McKenna A, et al. The somatic genomic landscape of glioblastoma[ J ]. Cell,2013,155 ( 2 ) : 462 - 477.
4Verhaak RG, Hoadley KA, Purdom E, et al. Integrated ge- nomie analysis identifies clinically relevant subtypes of glio- blastoma characterized by abnormalities in PDGFRA, IDH1, EGER,and NF1 [J]. Cancer Ce11,2010,17(1) :98 - 110.
5McLendon R, Friedman A, Bigner D, et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways [ J ]. Nature, 2008,455 ( 7216 ) : 1061 - 1068.
6Brennan C, Momota H, Hambardzumyan D, et al. Glioblasto- ma subclasses can be defined by activity among signal trans- duction pathways and associated genomic alterations [ J ]. PLoS One ,2009,4 ( 11 ) : e7752.
7John KW, Zheng S, Jelluma N, et al. Methylation of the PTEN promoter defines low - grade gliomas and secondary gliobtastoma [ J ]. Neuro 0neol,2007,9 (3) :271 - 279.
8Sumazin P, Yang X, Chiu HS, et al, An extensive microRNA -mediated network of RNA - RNA interactions regulates established oncogcnic pathways in glioblastoma [ J ]. Cell, 2011,147(2) :370 -381.
9Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers I J]. Sci- ence,2004,304 (5670) :554 - 559.
10Gallia GL, Rand V, Siu IM, et al. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme[ J]. Mol Cancer Res,2006,4(10) :709 - 714.
