摘要
目的:探讨脑卒中患者发病急性期血清白细胞介素-2(IL-2)水平的变化及意义。方法:采用酶联免疫吸附法(ELISA)测定34例缺血性卒中患者(包括急性脑梗死22例,短暂性脑缺血(TIA)12例),29例出血性卒中患者及健康对照者血清中IL-2的含量。结果:与正常对照组相比,急性脑梗死及脑出血患者IL-2水平均明显下降(P<0.01,P<0.05),TIA组略低于正常,但无统计学差异:结论:IL-2含量降低提示急性脑卒中患者免疫功能下降,与神经-免疫-内分泌网络结构及功能异常有关,并可能存在双向调节作用。
Objective: To study the change and significance of serum interlenkin-2 (IL-2) content in acute phase of stroke patients. Methods:ELISA was used to measure the serum IL-2 levels in 34 cases of patients with acute ischemic stroke including cerebral infartion(CI) and transient ischemic attack(TIA) .29 cases with cerebral hemorrhage(CH) and the normal group as control. The related analysis were performed. Results:Compared with the control group. IL-2 level of CI group and CH group showed a significant reduction (P<0.01, P<0.05 respectively). However, slight decrease in TIA group, but had no stastistical different. Conclusion:The reduction of IL-2 level indicated damage of immunity function in stroke patients. The change was closely related to the abnormality of nerve-immunity-endocrine system and mutural regulation might be existed.
出处
《临床急诊杂志》
CAS
2004年第5期9-10,共2页
Journal of Clinical Emergency
基金
武汉市卫生局临床重点学科研究基金 武卫[2002]219号
