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蛋白质芯片技术及其在传染病研究中的应用进展 被引量：1

Protein chip technology and its application in infectious disease research
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摘要 蛋白质芯片是一种新型的蛋白质功能分析技术,具有高通量、快速、敏感、准确、微型化和自动化等特点。它在传染病病原体的检测、毒力及致病机制、耐药机制的研究、宿主免疫机制的阐明、新替代疫苗的研制、新抗生素靶位的发现等方面将有着巨大的应用前景。本文就蛋白质芯片技术及其在传染病研究中的应用进展作了概述。
作者 张艳 范学工
机构地区 南华大学医学院医学微生物学与免疫学教研室 中南大学湘雅医院传染科
出处 《国外医学（流行病学．传染病学分册）》 2004年第5期304-308,共5页 Epidemiology Lemology Foreign Medical Sciences
关键词 传染病 蛋白质芯片技术 应用进展 靶位 蛋白质功能 巨大 致病机制 宿主免疫 毒力 疫苗
分类号 R51 [医药卫生—内科学]
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参考文献26

  • 1Lee Y, Lee EK, Cho YW, et al. ProteoChip: a highly sensitive protein microarray prepared by a novel method of protein immobilization for application of protein-protein interaction studies. Proteomics, 2003, 3 (12):2289-2304.
  • 2MacBeath G, Schreiber SL. Printing proteins as microarrays for highthroughput function determination. Science, 2000, 289 (5485): 1760-1763.
  • 3Diamond DL,Zhang Y,Gaiger A,et al. Use of ProteinChip array surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOFMS) to identify thymosin beta-4, a differentially secreted protein from lymphoblastoid cell lines. J Am Soc Mass Spectrum, 2003,14(7): 760-765.
  • 4Bacarese-Hamilton T, Bistoni F, Crisanti A. Protein microarrays: fromserodiagnosis to whole proteome scale analysis of the immune reslponse againstpathogenic microorganisms. Biotechniques,2002, Suppl: 24-29.
  • 5Solnick JV, Schauer DB. Emergence of diverse helicobacter species in the pathogenesis of gastric and enterohepatic diseases. Clin Microbiol Rev,2001,14:59-97.
  • 6Hynes SO, McGuire J, Wadstrom T. Potential for proteomic profiling of helicobacter pylori and other helicobacter spp. using a ProteinChip array.FEMS Immunol Med Microbiol,2003,36(3): 151-158.
  • 7HynesSO,McGuireJ,FaitT,etal. The rapid detection oflow molecular mass proteins differentially expressed under biological stress for four helicobacter spp.using ProteinChip technology. Proteomics,2003,3(3) :273-278.
  • 8Pavlickova P, Jensen NM, Paul H, et al. Antibody detection in human serum using a versatile protein chip platform constructed by applying nanoscale self-assembled architectures on gold. J Proteome Res, 2002,1(3) :227-231.
  • 9Smith D, Collins BD, Heil J, et al. Sensitivity and specificity of photoaptamer probes. Mol Cell Proteomics,2003,2(1): 11-18.
  • 10Perrin A, Duracher D,Perret M,et al. A combined oligonucleotide and protein microarray for the codetection of nucleic acids and antibodies associated with human immmodeficiency virus, hepatitis B virus, and hepatitis C virus infections. An Biochem,2003,322(2) :148-155.

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  • 1Wasinger VC, Cordwell SJ, Cerpa-Poljak A, et al. Progress with gene-product mapping of the Mollicutes: Mycoplasma genitalium[J].Electrophoresis, 1995, 16(7):1 090-1 094.
  • 2Anderson L, Seilhamer J. A comparison of selected mRNA and protein abundances in human liver[J]. Electrophoresis, 1997, 18(3-4):533 - 537.
  • 3Anderson NI, Anderson NG.Proteome and Proteomics: new technologies, new concepts, and new words[J] . Electrophoresis, 1998, 19:1 853-1 861.
  • 4Blackstock WP, Weft WP. Proteomics : quantitative and physical mapping of cellular proteins[J].Trends Biotechnol, 1999, 17(3):121- 127.
  • 5Emmert-Buck MR, Bonner RF, Smith PD, et al. Laser capture microdissection[J] . Science, 1996, 274(5289) :921 - 922.
  • 6O'Farrell PH. High resolution two-dimensional electrophoresis of proteins[J]. J Biol Chem, 1975, 250(10): 4 007-4 021.
  • 7Vitolins MZ,Anthony M, Burke GL Soy protein isoflavones, lipids, and arterial disease[J]. Curr Opin Lipidol, 2001, 12:433.
  • 8Barry RC, Msaker BL, Robison-Cox JF, et al. Quantitative evaluation of sample application methods for semipreparative separations of basic proteins by two-dimensianal gel electrophoresis[J] . Electrophoresis,2003, 24( 19-20): 3 390-3 404.
  • 9Yan JX, Devenish AT, Wait R, et al. Fluorescence two-dimensional difference gel electrophoresis and mass spectrometry based proteomic analysis of Escherichia coli[J] .Proteomics,2002,2(12) : 1 682- 1 698.
  • 10Ana M, Laura GG,Willy RG, et al. Derivatization of biomolecules for chemiluminesoent detection in capillary electrophoresis[J]. Analyt Technol Biomed Life Sci, 2003, 793 ( 1 ) : 49 - 74.

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国外医学（流行病学．传染病学分册）
2004年 第5期

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