期刊文献+

HIV基因治疗概况及进展 被引量:1

The general situation and progression of HIV genic treatment
在线阅读 下载PDF
导出
摘要 随着人免疫缺陷病毒(HIV)感染在全球的蔓延,寻求有效的治疗和预防方法成为当务之急。90年 代以来,人们开始探索基因治疗的新途径。基因治疗就是将外源性基因转移到合适的靶细胞中,使其表达为RNA 或蛋白质,在基因水平上改变病毒或宿主基因的表达,以达到控制病毒增殖的目的。
作者 陈亮 吴南屏
出处 《国外医学(流行病学.传染病学分册)》 2004年第5期265-268,共4页 Epidemiology Lemology Foreign Medical Sciences
  • 相关文献

参考文献14

  • 1Lee NS, Dohjima T, Bauer G, et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol,2002,20: 500-505.
  • 2Novina CD, Murray MF, Dykxhoom DM, et al. siRNA-directed inhibition of HIV- 1 infection. Nat Med, 2002,8: 681-686.
  • 3Jacque JM,Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature, 2002,418: 435-438.
  • 4Yamamoto T, Omoto S, Mizuguchi M, et al. Double-stranded nef RNA intefferes with human immunodeficiency virus type 1 replication. Microbiol.Immunol, 2002,46: 809-817.
  • 5Xia H, Mao Q, Paulson HL, et al. SiRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol,2002,20:1006-1010.
  • 6Ramezani A, Marhin W. Weerasinghe M, et al. A rapid and efficient system for screening HIV-1 pol mRNA-specific ribozymes . Can J Microbiol,1997,43(1):92-96.
  • 7Wang L, Witherington C, King A, et al. Prechnical characterization of an anti-tat ribozyme for therapeutic application. Hum Gene Ther, 1998, 9(9): 1283-1291.
  • 8Klebba C, Ottmann OG, Scher M. et al. Retrovirally express anti-HlV ribozymes confer a selective survival advantage on CD4+ T cells in vitro.Gene Ther,2000,7(5) :408-416.
  • 9Feng Y, Leavitt M, Tritz R, et al. Inhibition of CCR5-dependent HIV-1 infection by hairpin ribozyme gene therapy against CC-chemokine receptor 5.Virology,2000,276(2): 271-278.
  • 10Wong-Staal F, Poeschla EM, Looney DJ. A Controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.Hum Gene Ther, 1998,9(16) :2407-2425.

共引文献1

同被引文献4

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部