摘要
目的 :探讨先天性白内障的发病因素 ,提醒儿科医生重视眼科检查 ,以求尽早发现治疗先天性白内障 ,从而减少弱视和盲的发生。方法 :以 116名 1岁以内的先天性白内障患儿作为观察组 ;选取 10 2名健康儿童为对照组 ,进行病例对照研究 ,对 18种危险因素进行Logistic回归分析。结果 :母亲孕期存在贫血或缺钙、孕早期宫内病毒感染、自然分娩、异常分娩、家族史、早产双胎、窒息史、缺氧缺血性脑病、吸氧持续时间等 9种危险因素 ,观察组与对照组有显著性差异 ,多因素Logistic回归分析均表明吸氧持续时间、孕早期宫内病毒感染、家族遗传是先天性白内障的主要危险因素。结论 :通过研究先天性白内障的主要危险因素 ,特别提示儿科医生在儿童各阶段体检时应注意不要遗漏眼部检查 ,注意询问患儿吸氧情况 ,对那些开始吸氧时间早、持续时间长的患儿 ,建议请眼科医生详细检查患儿眼部情况 。
Objective:To explore the risk factors of congenital cataracts and emphasize the importance for the pediatrician to the screening of congenital cataract in the routine pediatric examination to prevent blindness.Methods:116 babies younger than 1 year were designed to be the study group and 102 age and sex matched healthy babies were designed to be the control group.All their (parents) were asked to answer 64 questions involving 18 risk factors.Logistic regression analysis for 18 kinds of risk factors was made.Results:The differences of duration of oxygen inspiration (X_(18)),viral infection during fetal period (X_(5)) and familial hereditary history (X_(10))between study group and control group are all significant.The logistic regression equation of congenital cataract risk factors was logit(P)=-0.5491+1.584X_(5)+1.327X_(10)+0.648X_(18)(χ~2=52.66,P=0.0000).Conclusions:It is extremely important for the pediatricians to pay more attention to the eye examination in the routine health examination to children with those risk factors.In such conditions,ophthalmologist should be asked to see the baby to avoid blindness as early as possible.
出处
《眼科》
CAS
2004年第5期288-290,共3页
Ophthalmology in China
