摘要
目的 观察针刺治疗对重度颅脑损伤患者脑脊液中白细胞介素 8(IL 8)、可溶性细胞粘附分子 1(sICAM 1)含量的影响 ,并探讨针刺治疗的脑保护作用机制。方法 5 0例重度颅脑损伤患者随机分为对照组和治疗组。对照组 (2 4例 )应用常规治疗 ,治疗组 (2 6例 )在常规治疗基础上于入院后第 1d起针刺涌泉和历兑穴 (时间为 30min ,1次 /d,共 7d) ,采用酶联免疫吸附方法 (ELISA)检测患者伤后 1、2、3、5、7d脑脊液中IL 8、sICAM 1含量。结果 ①对照组脑脊液中IL 8、sICAM含量在伤后1d升高 ,2d达高峰 ,3d开始下降 ,5d进一步下降 ,7d下降到正常水平 ;②治疗组脑脊液中IL 8、sICAM 1含量在伤后 1d升高 ,2d下降 ,3d继续下降 ,5d下降到正常水平 ;③治疗组伤后 2、3、5d脑脊液中IL 8、sICAM 1含量均低于对照组相应时相点脑脊液中IL 8、sICAM 1含量 (P <0 .0 5 )。结论 针刺治疗能减轻重度颅脑损伤后脑内炎症反应 ,从而减轻因炎症反应引起的继发性脑损害 。
Objective To observe the effect of acupuncture on the levels of Interleukin 8(IL 8) and soluble intercellular adhesion molecule 1(sICAM 1) in the cerebrospinal fluid (CSF) of patients with severe traumatic brain injury (STBI) and to investigate its cerebral protective mechanism.Methods Fifty cases with STBI were randomly divided into the treatment group (26 cases) treated with acupuncture besides the conventional therapy from the 1 st day after their admissions and the control group (24 cases) treated with conventional therapy. The levels of IL 8 and sICAM 1 in the CSF were measured by enzyme linked immunosorbent assay ( ELISA ) technique on the 1 st , 2 nd , 3 rd , 5 th and 7 th day after injury.Results ①In the treatment group, the levels of IL 8 and sICAM 1 in the CSF increased on the 1 st day after injury while they decreased on the 2 nd , 3 rd day and got to the normal range on the 5 th day after injury;②In the control group, the levels of IL 8 and sICAM 1 in the CSF were significantly increased on the 1 st day after injury; the highest level was got on the 2 nd day after injury , they decreased on the 3 rd , 5 th day and were in the normal range on the 7 th day;③The levels of IL 8 and sICAM 1 in the CSF of the treatment group were significantly lower than that of the control group on the 2 nd , 3 rd and 5 th day after injury respectively (p<0.05). Conclusion Acupuncture can obviously reduce the inflammatory reaction for the patients with STBI, consequently it alleviates secondary brain injury. It might contribute to a new therapeutic strategy for cerebral protection.
出处
《中华神经外科疾病研究杂志》
CAS
2004年第5期420-423,共4页
Chinese Journal of Neurosurgical Disease Research
