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羟乙基淀粉的研究进展 被引量：4

Hydroxyethyl starch:An ideal volume expander
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摘要 羟乙基淀粉 (商品名 :贺斯Hydroxyethylstarch ,HES)溶液的扩容强度和维持时间由其各自独特的分子质量、取代程度和取代方式决定的。HES能显著地改善血流动力学和血液流变学 ,具有独特的防止和堵塞毛细血管漏的作用。与其他胶体溶液相比 ,更加有效、安全和经济 。 Different preparations of Hydroxyethyl starch (HES) each have unique molecular weight, degree of substitution and manner of substitution, which are responsible for their intravascular volume expansion and half-life. HES solutions have notable effects on ameliorating hemodynamic and hemorrheological parameters, as well as unique capacity to prevent and reduce capillary leak. Compared with other colloid solutions, HES is more effective, safe and economical. It is an ideal volume expander.
作者 田婕 徐建国
机构地区 南京军区南京总医院麻醉科
出处 《医学研究生学报》 CAS 2004年第10期942-945,共4页 Journal of Medical Postgraduates
关键词 羟乙基淀粉 血流动力学 血液流变学 毛细血管漏 胶体溶液 Hydroxyethyl starch Hemodynamics Hemorrheology Capillary leak Colloid solutions
分类号 R973.5 [医药卫生—药品]
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参考文献27

  • 1[1]Baron JF. Adverse effects of colloids on renal function. In: Vincent JL. Yearbook of intensive care and emergency medicine[M]. Berlin: Springer, 2000. 486-493.
  • 2[2]Treib J, Haass A, Pindur G et al. All medium starches are not the same: influence of the degree of hydroxyethyl subst: tution of hydroryethyl starch on plasma volume, hemorrheologic conditions, and coagulation [J]. Transfusion, 1996, 36(5): 450-455.
  • 3[3]Baron JF. Crystalloids versus colloids in the treatment of hypovolemic shock. In: Vincent JL, eds. Yearbook of intensive care and emergency medicine[M]. Berlin: Springer, 2000. 443-466.
  • 4[4]Boldt J, Lehmann A, Rompert R et al. Volume therapy with a new hydroxyethyl starch solution in cardiac surgical patients before cardiopulmonary bypass [J]. J Cardiothorac Vasc Anesth, 2000, 14(3): 264-268.
  • 5[5]Dehne MG, Muhling J, Sablotzki A et al. Hydroxyethyl starch (HES) does not directly affect renal function in patients with no prior renal impairment [J]. J Clin Anesth, 2001, 13(2): 103-111.
  • 6[6]Schaefer CF, Lerner MR, Biber B. Oxygen metabolism changes and outcome in response to immediate colloid treatment in the endotoxaemic rat [J]. Acta Anaesthesiol Scand, 1995, 39(1): 43-49.
  • 7[7]Asfar P, Kerkeni N, Labadie F et al. Assessment of hemodynamic and gastric mucosal acidosis with modified fluid versus 6% hydroxyethyl starch: a prospective, randomized study [J]. Intensive Care Med, 2000, 26(9): 1282-1287.
  • 8[8]Kaneki T, Koizumi T, Yamamoto H et al. Effect of resuscitation with hydroxyethyl starch (HES) on pulmonary hemodynamics and lung lymph balance in hemorrhagic sheep: comparative study of low and high molecular HES[J]. Resuscitation, 2002, 52(1): 101-108.
  • 9[9]Kobori M, Negishi H, Nagai H et al. Plasma substitute for replacement in hemorrhagic shock: comparison of low and medium weight hydroxyethyl starch [J]. Current Therapeutic Res, 2000, 61(7): 414-421.
  • 10[10]Suzer O, Koseoglu S, Han G. No beneficial effects of isocolloidoosmotic synthetic colloid addition to St. Thomas hospital cardioplegic solution in ischemia-reperfusion injury in isolated perfused rat hearts [J]. Gen Pharmac, 1999, 32(1): 101-105.

同被引文献35

引证文献4

二级引证文献8

医学研究生学报
2004年 第10期

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