树突状细胞在支气管哮喘发病机制中的作用
Role of dendritic cells in pathogenesis of bronchitic asthma
摘要
树突状细胞(DCs)作为功能最强的抗原递呈细胞,不仅能刺激初始型T细胞增殖,还能刺激已活化或记忆型T细胞。本文通过研究过敏性哮喘模型气道中DCs数量增加,提示DCs在支气管哮喘的发病机制中起重要作用,且DCs在以Th2反应增强为主要免疫病理改变中占重要地位。
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第10期892-894,共3页
Journal of Applied Clinical Pediatrics
参考文献17
-
1Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection[J ]. Curr Opin Immunol, 1999,11 (4): 392 - 399.
-
2Randolph G J, Baulieu S, lebecque S, et al. Differentiation of monocytes into dendritic cells in a moxel of transendothelial trafficking[J]. Science, 1998,282(5388) :480 - 483.
-
3Schwartj R. A new element in the mechanism of asthma[J]. New Engl J Med,2002,346 ( 11 ): 857 - 858.
-
4Cravens PD, Lipsky PE. Dendritic cells, chemokine receptors and autoimmune inflammatory diseases[J ]. Immunol Cell Biol,2002,80(5) :497 - 505.
-
5赵顺英.哮喘发病机制研究进展[J].实用儿科临床杂志,2003,18(10):768-771. 被引量:60
-
6Reid SD, Penna G, Adorini L. The control of T cell responses by dendritic cell subsets[J ]. Curr Opin Immunol, 2000,12( 1 ): 114 - 121.
-
7Reider N, Reider D, Ebner S, et al. Dendritic cells contribute to the development of atopy by an insufficiency in IL- 12 production[J ]. J Allergy Clin Immunol, 2002,109 (1) :89 - 95.
-
8Matsuda H, Suda T, Hashizume H, et al. Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma[J ]. Am J Res Crit Care Med,2002,166(8): 1050 - 1054.
-
9Masten BJ, Lipscomb MF. Dendritic cells: pulmonary immune regulation and asthma[J]. Monaldi Arch Chest Dis,2000,55(3) :225 - 230.
-
10Sallusto F, Lanzavecchia A. Understanding dendritic cell and Tlymphocyte traffic through the analysis of chemokine receptor expression[J ]. Immunol Rev, 2000,177:134 - 140.
二级参考文献20
-
1The global initiative for asthma. Global strategy for asthma management and prevention: mechanisms of asthma[ M]. NewYork:National institutes of health, 2002.50- 54.
-
2Holgate ST,Lackie PM,Davies DE,et ad. The bronchial epithelium as a key regtdator of airway allergy sensitization and remodeling in asthma [J ]. Am J Respir Crit Care Med, 2000, 162:Sl13S117.
-
3Akizanha H, Airway epithelial cells as regulators of airway inflammatory[J ].Int J Mol Med, 1998,1 : 367-- 378,.
-
4Trennard SI, Repair mechanisms in asthma[J ], J Allergy Clin Immunol, 1996,98: 278 -- 286.
-
5Holgate ST, Epithelial damage and response[J], Clin Exp Allergy,2000,30 : 137-141.
-
6Davies DE. The bronchial epithelium:translating gene and environment interactions in asthma[J ]. Curr Opin Allergy Clin Immunol,2001,1 :67--71.
-
7Bucchieri F, Lordan J, Richter D, et al. Increased sensitivity of asthmatic bronchial epithelial cells to oxidant-induced injury[J].Am J Respir Crit Care Med,2000,161 : A153.
-
8Devalia JL, Bayram H, Abdelazizkhair OA. Comparision of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatics and atopic asthmatic patients, and effect of diesel exhaust particlesin vitro [ J ]. J Allergy Clin Immunol, 1998,102: 771 -- 782.
-
9Holgate ST, Daavies DE. The conquest of allergy: epithlial mesenchymal interactions in the pathogenesis of asthma[J ]. J Allergy Clin Immunol,2000,105(2): 193-196.
-
10White SIR, Dorscheid DR. Corticosteroid-induced apoptosis of airway epithelium:a potential mechanism for chronic airway epithelial damage in asthma[J] .J Allergy Clin Immunol,2002,110(6)873--878.
共引文献59
-
1王成林,龚放,黄兆敏,黄瑛.孟鲁司特钠佐治哮喘38例疗效观察[J].实用儿科临床杂志,2004,19(10):885-886. 被引量:15
-
2张淑玲,常全忠.儿童支气管哮喘发低钾血症相关因素分析[J].新乡医学院学报,2004,21(6):477-478. 被引量:1
-
3杨莉,王文建,王西华,李海浪.川芎嗪对哮喘大鼠气道壁胶原沉积和转化生长因子-β_1表达的影响[J].实用儿科临床杂志,2004,19(12):1028-1029.
-
4杨俭治,郑敬阳,苏梅玉,卓志强.沙美特罗替卡松干粉剂吸入治疗哮喘140例[J].实用儿科临床杂志,2004,19(12):1084-1085. 被引量:2
-
5齐静姣,张平.急性哮喘患儿体内T细胞亚群动态变化及临床意义探讨[J].临床医学,2005,25(1):1-2. 被引量:3
-
6谢庆玲,焦伟,温志红,谭颖,胡琼燕.孟鲁司特对儿童哮喘炎症因子的影响[J].实用儿科临床杂志,2005,20(4):308-310. 被引量:13
-
7王秀娟,曲书强,付迎新,刘树胜.哮喘患儿血清白细胞介素-16、-10和免疫球蛋白E测定的意义[J].实用儿科临床杂志,2005,20(7):670-671. 被引量:3
-
8翁小斌,鲍金芳.哮喘患儿血清IL-10、IL-8水平和峰流速值变化的研究[J].临床医学,2005,25(8):22-23.
-
9罗会玉,沈照波,汤昱.两种吸入方式治疗哮喘急性发作的效果[J].实用儿科临床杂志,2005,20(10):956-956. 被引量:2
-
10刘力戈,侯安存,方惠秋,郝艳艳.支气管哮喘患儿血T辅助淋巴细胞的变化[J].实用儿科临床杂志,2006,21(4):217-218. 被引量:26
-
1王宇清,朱灿红,季伟.吸入性糖皮质激素对哮喘重塑模型气道纤维化的影响[J].苏州大学学报(医学版),2005,25(4):589-591. 被引量:1
-
2于加海,李锦亮,岳保珠.儿童哮喘血清中SP-A、SP-D、IL-8、IgE的水平变化及临床意义[J].中国优生与遗传杂志,2012,20(11):119-121. 被引量:3
-
3段国威,李芳,王炜,任建峰,宋青.肺炎支原体肺炎患儿免疫状态的研究[J].中国综合临床,2012,28(8):879-880. 被引量:11
-
4康妍萌,丁明杰,韩玉玲,王世富,马香,李华.重症肺炎支原体肺炎患儿肺泡灌洗液中Th1/Th2细胞免疫应答状况的研究[J].中国当代儿科杂志,2011,13(3):188-190. 被引量:56
-
5王植嘉,尚云晓,蔡栩栩,陈宁,舒林华,单丽沈,张晗,李想.特应性体质与哮喘患儿呼出气一氧化氮相关性分析[J].中国实用儿科杂志,2012,27(6):462-463. 被引量:12
-
6孟云,吕书博,赵德华,刘锐娟,张展.影响新生儿苯丙酮尿症检出的因素探讨[J].疾病监测与控制,2014,8(8):522-523.
-
7王芳,肖慧捷,丁洁,闫辉,金怡文,刘建.不典型急性链球菌感染后肾小球肾炎3例报告[J].临床儿科杂志,2012,30(7):646-650. 被引量:10
-
8孙立锋,杨锡强.树突状细胞与支气管哮喘[J].临床儿科杂志,2004,22(2):119-121. 被引量:8
-
9王俊,韩晓华,杨柏松,尚云晓,刘春峰,蔡栩栩.肺炎支原体肺炎患儿血清及诱导痰中白细胞介素-4及γ-干扰素的测定[J].中国实用儿科杂志,2005,20(9):543-545. 被引量:44
-
10李永柏,沈锦,张恒言,梁大才,徐培菊,车秋,张远维,王莉佳.小儿肾小球疾病尿免疫复合物检测与肾免疫病理学对比研究[J].重庆医科大学学报,1996,21(2):123-127.