摘要
目的 探讨 2型糖尿病患者血小板激活与血小板源微颗粒 (PDMP)的关系。方法 分为 :2型糖尿病组 (A组 )、正常糖耐量组 (B组 )两组。用CD6 2P FITC单克隆抗体标记激活的血小板 ,CD4 2a PE单克隆抗体标记PDMP ,流式细胞仪检测单克隆抗体。结果 对两组CD6 2P、CD4 2a均数进行t检验 ,差异有显著性 (P <0 0 1)。相关分析显示CD6 2P与CD4 2a具有相关性 (P <0 0 1)。多元回归分析显示CD6 2P是CD4 2a的独立影响因素。结论 A组血小板激活较B组显著增强 ,同时伴有血小板微颗粒释放。
Objective In the study we detected CD62P and PDMP of patients with or without type 2 diabetes in order to find the relations between them. Methods Activated platelets(detected by CD62P) and microparticles (PDMP,detected by CD42a) were analysed by flow cytometry. Results Group of Type 2 diabetic patients:CD62P(8.86±3.55)%,CD42a(15.53±4.43)%. Group of normal glucose tolerance(NGT): CD62P (5.79±2.52)%, CD42a (10.03±7.31)%. There were siginificant differences in CD62P and CD42a between the two groups.CD62P significant relationship with CD42a. Stepwise multiple linear regression analysis suggested that the independent risk predictor for worsening CD42a was CD62P. Conclusion The study show that there was significant relationship between PDMP and activate platelets in patients with diabetes. With the platelets being activated, the PDMP has been released,suggesting that PDMP may participate in the development of vascular complications with coagulability
出处
《安徽医科大学学报》
CAS
2004年第5期381-383,共3页
Acta Universitatis Medicinalis Anhui
基金
安徽省自然科学基金资助项目 (编号 :0 3 0 43 719)
