摘要
目的 :超声检测血管内皮硝酸甘油 (GTN)依赖性及非依赖性舒张功能 ,研究冠心病患者血管内皮功能的变化及其临床意义。 方法 :12 0例被检查者均为住院治疗并接受冠状动脉造影的患者 ,应用高频超声检测肱动脉血流介导及硝酸甘油引起的舒张反应。 结果 :①总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)水平及高血压、糖尿病发病率在冠心病组中明显高于对照组。②冠心病组的肱动脉基础内径略大于对照组 ,但无统计学意义 (P >0 .0 5 )。冠心病组由血流介导以及硝酸甘油引起的肱动脉舒张反应均明显低于对照组 (P <0 .0 1)。 结论 :在冠心病患者和有危险因素的人群中开展血管内皮功能检查 ,可为早期发现、预防和治疗冠心病提供依据 ,还可作为监测和评估病情变化的指标。
Objective: To investigate the dilatation changes of brachial artery during reactive hyperemia and after sublingual administraction of glyceryl trinitrate, to analysis the clinic significance. Methods: Using B-mode ultrasonography, measuring the dilatation of brachial arteries during reactive hyperemia and after sublingual administraction of glyceryl trinitrate in 120 patients. Results: ①The level of TC, LDL-C and incidence rate of hypertention, diabetes mellitus were higher in CHD group. ② The flow-mediated dilatation and GTN-induced dilatation of brachial artery in patients with CHD were significantly reduced as compared with those in controled group(P<0.01). Conclusion:In patients with CHD and persons with CHD risk factors, Using B-mode ultrasonography to investigate the endothelial function can provide evidence of CHD in earlier period, it can be also used to monitor patient's condition and prognosis.
出处
《医学研究生学报》
CAS
2004年第9期799-801,804,共4页
Journal of Medical Postgraduates
基金
全军医药卫生科研基金资助课题 (批准号 :0 2M0 0 7)
关键词
超声
血管内皮功能
冠心病
硝酸甘油
危险因素
Ultrasound
Endothelial function
Coronary heart disease
Glyceryl trinitrate
Risk factor
