摘要
肝内胆汁淤积是指任何病因引起肝细胞和(或)毛细胆管胆汁分泌功能障碍,或肝内小胆管弥漫性梗阻所致的一系列的病理和临床表现.其中具有遗传倾向性和(或)有明确致病基因突变的胆汁淤积称为原发性肝内胆汁淤积,而由于后天获得性因素如药物、内毒素、激素、胆道梗阻、肝移植、全胃肠外营养等所致者则称为继发性肝内胆汁淤积.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2004年第8期633-635,共3页
Chinese Journal of Internal Medicine
参考文献13
-
1Kurbegov AC, Setchell KD, Haas JE, et al. Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile. Gastroenterology, 2003, 125:1227-1234.
-
2Bull LN, van Eijk MJ, Pawlikowska L, et al. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet, 1998, 18:219-224.
-
3Jansen PL, Strautnieks SS, Jacquemin E, et al. Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. Gastroenterology, 1999, 117:1370-1379.
-
4Oude Elferink RP, Groen AK. Mechanisms of biliary lipid secretion and their role in lipid homeostasis. Semin Liver Dis, 2000, 20:293-305.
-
5Setchell KD, Schwarz M, O′Connell NC, et al. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J Clin Invest, 1998, 102:1690-1703.
-
6Savander M, Ropponen A, Avela K, et al. Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy. Gut, 2003, 52:1025-1029.
-
7Jacquemin E, Cresteil D, Manouvrier S, et al. Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. Lancet, 1999, 353:210-211.
-
8Jones DE, Watt FE, Metcalf JV, et al. Familial primary biliary cirrhosis reassessed: a geographically-based population study. J Hepatol, 1999, 30:402-407.
-
9Medina JF, Martinez-Anso, Vazquez JJ, et al. Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology, 1997, 25:12-17.
-
10Zollner G, Fickert P, Silbert D, et al. Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J Hepatol, 2003, 38:717-727.
-
1宗蕾,陆伦根.肝内胆汁淤积发病机制的研究进展[J].临床消化病杂志,2009,21(3):133-135. 被引量:2
-
2胡电,古航,刘彦,曹立萍,穆燕,李萍.妊娠肝内胆汁淤积并发胎儿宫内窘迫与一氧化氮的关系[J].第二军医大学学报,2002,23(8):827-827.
-
3潘红英,童永喜,陈素莲,蒋兰英.Dubin-Johnson综合征6例[J].浙江医学,2002,24(9):565-565. 被引量:2
-
4张燕,申德林,朱晓红.Dubin-Johnson综合征长期误诊为酒精性肝炎1例[J].实用医药杂志,2004,21(10):880-880.
-
5徐瑛,王慧芬,张爱民.Dubin-Johnson综合征合并慢性乙型肝炎1例[J].世界华人消化杂志,2005,13(1):154-154.
-
6王萍,商庆华.Dubin-Johnson综合征长期误诊1例[J].临床军医杂志,2004,32(4):51-51. 被引量:1
-
7梁立维,张建民,蔡祖金,张晓云,杨伟刚.Dubin-Johnson综合征一例[J].中华消化杂志,2002,22(8):480-480.
-
8林萍,邓明德.Dubin-Johnson综合征1例[J].西北国防医学杂志,2010,31(6):418-418. 被引量:1
-
9王文琼.中西医结合治疗妊娠肝内胆汁淤积20例[J].现代中西医结合杂志,2008,17(8):1219-1220. 被引量:1
-
10邵鸣,肖玉珍.Dubin-Johnson综合征1例[J].肝脏,2010,15(6):480-480.