摘要
目的 :分析IgE型多发性骨髓瘤临床及实验室特征。方法 :文献复习并报告本院收治的 1例 5 2岁女性 ,因进行性加重的腰背部疼痛就诊。X线及核素扫描提示第 8、11、12胸椎、第 1腰椎压缩性骨折及骨盆、脊椎普遍性骨质疏松。除了血沉增快、血红蛋白轻度下降、血钙和尿素轻度升高外 ,常规生化结果均在正常参考范围内。结果 :血清蛋白电泳提示在γ球蛋白组份中出现M蛋白 ,血清免疫固定电泳证实存在IgE κ型M蛋白 ,尿中本 周蛋白阳性。骨髓穿刺骨髓原浆 +幼浆细胞占有核细胞 72 .8%。根据其临床与实验室特点诊断为IgE型多发性骨髓瘤。结论 :分析该患者及文献报告的IgE型多发性骨髓瘤患者的资料 。
Objective: The clinical and laboratory features of an IgE multiple myeloma were analyzed. Methods: A 52-year-old woman admitted with progressive lumbago and weakness was reported and with literatures review. X rays and bone scan of this patient showed multiple compression fractures at T_(8)、T_(11)、T_(12)、L_(1 )and osteoporosis of pelvis and all vertebrae. With the exception of hypersedimentation rate, mild decreased hemoglobin, mild hypercalcemia and elevated blood urea, routine biochemistry values were within reference limits. Plasma cell was not observed in the peripheral blood. Results: Serum protein electrophoresis showed a monoclonal protein in the gammaglobulin fraction. Immuofixation confirmed the presence of an IgE kappa monoclonal protein. A bone marrow smear revealed abnormal plasma cells account for 72.8%of nucleated cells. Bence-Johns protein was detected in the urine. The diagnosis of IgE-κ multiple myeloma was established for this patient from the clinical, laboratory and radiological data. Conclusion: The findings for this patient were compared with the previous reports of IgE myeloma. It was concluded that IgE multiple myeloma exhibited some special clinical and laboratory features.
出处
《内科急危重症杂志》
2004年第3期135-137,共3页
Journal of Critical Care In Internal Medicine
