摘要
目的 探讨不同剂量13 1I治疗甲状腺功能亢进症的最佳治疗方法。方法 1998年 1月～ 2 0 0 1年12月 30 0例甲亢患者 ,平均随机分为三组 ,准确测定甲状腺TUK和EHL ,且EHL >3d ,甲状腺质量由核素显像确定 ,W =A×H×K。大剂量 (5 5 5MBq/g)组一次性全量 ;中剂量 (3 7MBq/ g)组一次性全量 ,3月后复查 ,酌情研究重复治疗或观察 ;小剂量 (2 5 9MBq/g)组 ,小剂量多次治疗 ,三个月为一疗程 ,直到治愈或好转。 结果 大剂量组 :治愈 94例 ,好转 6例 ,暂时性甲低 18例 ,永久性甲低 2 1例 ;中量组治愈 89例 ,11例好转 ,暂时性甲低 9例 ,永久性甲低 13例 ,1例 15个月后复发 ;小剂量组治愈 86例 ,14例好转 ,暂时性甲低 3例 ,永久性甲低 9例 ,4例复发。结论 13 1I治疗甲状腺功能亢进症效果肯定 ,治愈率高。三组治愈率 (χ2 =3 5 777,P >0 .0 5 )差别无显著性 ,而甲低发生率 (χ2 =6 0 6 0 ,P <0 .0 5 )
Objective To explore the best therapeutic method of different dose 131I to treat hyperthyroidism.Methods 300 hyperthyroidism cases were randomizedly divided into 3 groups from January 1998 to December 2001,and the thyroid TUR and EHL were measured accuratedly,and EHL>3d,W=A×H×R,thyroid quality was established by nucleatin development.Large dose group is 5.55MBq/g,and was given once full dose middle dose 3.7MBq/g,and was counterchecked after 3 months,and was retreated or observed by therapeutical situation;small dose group is 2.59MBq/g,with small dosage multitreatment.One course of treatment is 3 months and until cure or improvement.Results In large dose group 94 patients were cured and 6 patients were improved and transient hypothyreosis was 18 cases and 21 cases were permanent hypothyreosis,in middle dose group:89 cases cured,11 cases better,9 cases transcient hypothyreosis,13 cases permanent hypothyreosis,and one was recurrence after 15 months.In small dose group,86 cases were cured,14 patients were improved,transient hypothyreosis was 3 cases and 9 cases were permanent hypothyreosis,and 4 cases were recurrence.Conclusion The effectiveness is certain for 131I to treat hyperthyroidism with high cure rate.Three groups'cure rate (χ 2=3.5777,P>0.05)have no significant differene.Hypothyreosis ocurrennce rate (χ 2=6.060,P<0.05) have significant differene.
出处
《医药论坛杂志》
2004年第14期31-32,34,共3页
Journal of Medical Forum
