摘要
目的 观察川芎嗪、大黄联合治疗对慢性肾衰(CRF)患者细胞因子、内毒素和肾功能的影响。方法 将52例CRF患者按临床分期随机分为观察组和对照组,两组均给予常规治疗,观察组在此基础上给予川芎嗪注射液静脉滴注和大黄灌肠联合治疗,比较两组治疗前后各期血浆TNF-α、IL-6、LPS浓度变化和肾功能改善情况。结果 随着CRF病情恶化,血浆TNF-α、IL-6和LPS浓度明显升高,经治疗后两组各期血浆,INF-α、IL-6和LPS下降,肾功能有所改善。但观察组氮质血症期和肾衰竭期改善更加明显,差别有显著性(P<0.05)。结论 川芎嗪和大黄联合治疗CRF,通过抑制和拮抗细胞因子和内毒素,减轻免疫炎症反应,改善肾功能,延缓CRY的恶化,早中期疗效较好。
Objective To investigate the changes of plasma cytokines, plasma LPS and renal function in treating patients with chronic renal failure(CRF). Methods 52 cases with CRF in various clinical stages were collected and the patients lying in each stage were randomly divided into experimental group and contrastive group respectively. Patients in both groups received the routine treatment, but those in experimental group additionally received Chuanxiongqin and Rhubarb treatment. We observed both plasma levels change of TNF-α, IL-6, LPS and the improvement of renal function before and after treatment. Results The plasma levels of TNF-α, IL-6 and LPS elevated significantly going with the aggravation of CRF and decreased after treatment. Simultaneously, the renal function was improved. The improvement was most obvious in patients lying in early and medium stage of experimental group in comparison with that in the end stage of this group and all of contrastive group(P<0.05). Conclusion Chuanxiongqin and Rhubarb can lower immuno-inflamematory response by in hibiting cytokines and LPS, improve renal function and postpone the depravation of CRF. The curative effect is satisfactory in early and medium stages of CRF.
出处
《咸宁学院学报（医学版）》
2004年第3期184-186,共3页
Journal of Xianning Univarsity(medical Sciences)
