摘要
在-80℃条件下,以3 氟丙基苯为原料,通过与丁基锂、硼酸三甲酯和过氧化氢反应,新路线制备了中间体2 氟 4 丙基苯酚收率为76%(老方法收率为15%)。通过酯化合成了液晶化合物反式 4′ (4″ 丙基环己基)环己基甲酸2 氟 4 丙基苯酚酯,两步总收率为62%。目标化合物经IR,1HNMR,MS和元素分析确认了分子结构,液晶的相变温度通过差热扫描仪测定。
2-Fluoro-4-propylphenol was prepared by a new method from 3-fluoropropylbenzene at -80 ℃ with n -BuLi,B(OCH_3)_3 and H_2O_2 in 76% yield.By contrast,the yield of old method is 15%.Through esterification,liquid crystal ester 2-fluoro-4-propylphenyl trans -4-(4-propylcyclohexyl)cyclohexylcarboxylate was synthesized.Total yield of two steps was 62%.Its structure was confirmed by IR,~1HNMR,MS and elementary analysis,and the phase transition temperature was measured by DSC.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2004年第8期561-562,566,共3页
Fine Chemicals
