摘要
目的 :比较国产和进口阿卡波糖的降糖效果和安全性 ,及其对胰岛素水平、体重及血脂的影响。方法 :4 6例 2型糖尿病患者随机分组进行阳性对照试验 ,疗程 8周。结果 :与用药前相比 ,国产和进口阿卡波糖组的空腹及餐后血糖、胰岛素水平均明显降低 (P <0 .0 1) ;两组血脂及体重指数也有一定程度的下降。胃肠道等不良反应随服药时间的延长有缓解趋势。结论 :阿卡波糖是治疗 2型糖尿病和改善胰岛素抵抗安全有效的药物 。
Objective:To study the efficiency and safety of the domestic and imported acarbose in type 2 diabetes patients,and the effect on insulin levels,body weight and serum lipids.Methods:46 patients with type 2 diabetes were randomly assigned to receive treatment with domestic and imported acarbose for eight weeks.Results:After 8 weeks of treatment, the mean of fasting blood glucose(FBG) and the mean 2 hour postprandial blood glucose(PBG2h) decreased significantly in both study groups(P<0.01).The 2 hour postprandial insulin levels were reduced (11.03 mIU/L)(P<0.01)in the domestic group,and 19.83 mIU/L( P<0.01)in the imported group.Both acarbose therapies statically decreased serum lipids and BMI.There was no significant difference between the two groups regarding these changes.Conclusion:The domestic and imported acarbose have similar efficiency and safety both of them ameliorate insulin resistance.
出处
《中日友好医院学报》
2004年第4期226-228,共3页
Journal of China-Japan Friendship Hospital
关键词
阿卡波糖
2型糖尿病
胰岛素抵抗
血脂
体重
acarbose
type 2 diabetes
insulin resistance Author′s Address Department of Endocrinology,China-Japan Friendship Hospital,Beijing,100029,China
