摘要
本文采用游离二氧化硅含量极微的三种谷物粉尘进行肺灌洗试验及体内致纤维化实验研究。结果表明:三种谷尘染尘早期引起肺炎症细胞的大量浸入,随染尘时间的延长,巨噬细胞数明显增多,尤以谷壳尘增多更为明显,体内致纤维化实验结果也证明:三种谷尘染尘早期主要引起肺内肉芽肿,广泛的细支气管炎和间质纤维组织增生。谷壳尘实验终期出现少量排列不规则的胶原纤维。因此认为:含游离二氧化硅低的谷尘致纤维化作用较弱。
In this paper, bronchoalveolar lavage (BAD and pulmonary fibrosis were studied by the three different kinds of grain dusts containing very little free SiO2.The results showed that the number of inflammatary cells of BAL of all three kinds of grian-injected groups revealed increasing in the early stage.The number of alveolar macrophagc was singnificantly increased in those with injection of dust, particularly the grain shell dust,But .there was no significant action for maorophage cytoxicity of the three kinds of grain dusts. Pulmanary fibrosis study also suggested that histopathological changes in the lung with injection of grain dust were granuloma, diffusible bronchiolitis and interstitial fibrosis at an early stage. A few collagen fibers with ungeneral arrangment were observed on injection of grain shell dust at later stage. Therefore, the fibrosis effect of grain dust containing very little free SiO2 was mild.
出处
《工业卫生与职业病》
CAS
CSCD
1993年第6期328-331,共4页
Industrial Health and Occupational Diseases
关键词
谷尘
肺灌洗
纤维化
grain dust
bronchoalveaolar lavage (BAL)
fibrosis
