摘要
本研究观察了轻质油(45℃馏分)蒸气急性(30000mg/m^3和15000mg/m^3×8小时)和亚急性(3000mg/m^3×6小时/天×30天)动式染毒条件下,成年大鼠睾丸生化指标的改变。结果表明:(1)各实验组大鼠睾丸匀浆中LDH总量,LDH-X含量,与空白对照组比较无显著性变化(P>0.05)。(2)各实验组睾丸匀浆中游离型溶酶体酶β-D-半乳糖苷酶(β-D-G)、结合型β-D-G以及β-D-G游离酶/结合酶比值与空白对照组比较,差别不显著(P>0.05)。结合精子形态学检查结果,我们认为,在本实验浓度范围内,实验性急性、亚急性吸入轻质油(45℃馏分)蒸气对动物的生殖系统影响不明显。
This study was designed to approach the effect of light oil vapour on LDH-X and lysosomal enzymes of rat testis. Two concentrations were used for acute groups.One was 15000mg/m3, and the other was 30000mg/m3. Both of them were given for 8 hours. A concentration of 3000mg/m3 was given as subacute group for 6 hours per day and lasted for 30 days. The rats administered CdCU (1.5mg/kg i. p. ) served as positive controls. The results are as follows: (1) There were no significant differences between experimental groups and negative control in the activities of LDH and its isozyme.(2)In testis free and bound β-D-Galactosidase (β-D-G) and the ratio of β-D-G free/bound activities, the differences between all the experimental group and negative control were not statistically significant (P>0.05). According to the results of this study and the sperm morphological tests ,we considered that there were no sign ificant affect on male reproductive system after breathing light oil vapour.
出处
《工业卫生与职业病》
CAS
CSCD
1993年第4期216-219,共4页
Industrial Health and Occupational Diseases
基金
交通部"七.五通达计划"资助项目
关键词
轻质油
蒸气
生殖系统
毒性
light oil vapour
lactate dehydrogenase-X (LDH-X)
β-D-Galactosidase (β-D-G)
