摘要
我们曾合成了一系列铜的大环配合物,在生物体系中有强的SOD活性。为寻求稳定性高且活性也高的Mn-SOD模拟物,我们用Ba^(2+)及Pb^(2+)为模板剂合成了2个新的锰大环和1个锰开环配合物(图1),探讨了其活性和结构的关系,同时还合成了一些锰的羧酸盐配合物与之比较。结果表明,大环配合物的活性比前人作为Mn-SOD模拟物的羧酸盐配合物的高,这为获得Mn-SOD模拟物提供了有益的启示。
We synthesized two macrocyclic and one noncyclic manganese ( Ⅱ ) complexes for simulating Mn-superoxide dismutase(SOD). They were characterized by several physical methods and their structures were identified. Among the three complexes the macrocyclic mononuclear complex has a higher SOD activity than that of the manganese ( Ⅱ ) complexes of carboxylates which were considered as being good model compounds of Mn-SOD. The relationship between the SOD activity and structure of the complexes was discussed.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1993年第3期317-319,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
大环
活性
锰络合物
SOD
Manganese complexes, Macrocyclic, Superoxide dismutase, Activity
