摘要
一个急性髓系白血病高发家系的11名血缘亲属、4名非血缘亲属和10名正常对照进行外周血淋巴细胞的细胞周期时间(Tc),姐妹染色单体交换率(SCE)、银染核仁形成区(AgNOR)和银染近端着丝粒染色体的随体联合(Ag-AA)等检查,发现至少2名血缘亲属Tc延长、SCE和AgNOR异常,可能是白血病高危个体,正在进一步随访中。
On this papter, peripheral lymphocytic cell cycle (Tc), sister chromotid exchanges (SCE), Ag- stained nucleolus organizer regions (Ag-NOR) and Ag-stained satellite associations (Ag-AA) were in- vestigated in 11 pedigrees and 4 married relations of a family with 7 cases of acute myeloid leukemia during the past 16 years,and 10 non-relative subjects as normal controls. We found that SCE/cell and Ag-NOR/cell were lower in pedigreed relations than in normal controls. At least 2 of the pedigreed rela- tions showed several abnormalities, including prolonged Tc,abnormal SCE and Ag-NOR. They might be the high-risk individuals of acute leukemia. The follow-up is being made.
基金
福建省卫生厅科研基金(课题号:90C04)
