摘要
用放免分析法测定恶性血液187例血清叶酸(FA)值明显降低,151例血清维生素B_(12)(B_(12))值明显增高;化疗未缓解组(含部分缓解),血清FA虽有上升,B_(12)亦有下降,但与治疗前相比,无明显差异;完全缓解组FA明显上升,B_(12)值明显下降,与治疗前相比差异有显著性。对部分病例进行动态观察,进一步证实上述结果。提示血清FA,B_(12)含量与恶性血液病病情转归密切相关。
Serum folic acid and VitaminB_(12) (B_(12)) concentrations were measured with radioimmunoassay in patients with hematologic malignancies. The results showed that the serum folic acid value in 187 patients with hematologic malignancies was significantly decreased and the serum B_(12) value in 151 patients was elevated statistically. After chemotherapy the folic acid value in patients with partial or no remission was increased insignificantly and the B_(12) value was decreased, both were stutistically insignificant as compared with those before chemotherapy. However,in patients with complete remission the folic acid value was increased and the B_(12) value reduced significantly as compared with those before chemotherapy. Serial determinations suggest that the folic acid and B_(12) concentrations are closely correlated to the outcome of hematologic malignancies.
关键词
血液病
血清叶酸
维生素B12
hematologic malignancies
leukemia
serum folic acid
serum vitamin B_(12)
