反义寡核苷酸疗法在泌尿系肿瘤中的应用
摘要
反义寡核苷酸疗法是基因疗法的一种。近年来 ,反义寡核苷酸疗法在肿瘤治疗的应用已经由实验室阶段发展到临床试验阶段 ,包括泌尿系肿瘤。临床前期试验已经发现这种疗法可以对很多新发现的癌基因产生有治疗意义的抑制作用。本文主要综述了目前反义寡核苷酸疗法在泌尿系肿瘤中的应用现状。
出处
《国外医学(泌尿系统分册)》
2004年第4期457-460,共4页
Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
参考文献22
-
1Askari FK,McDonnell WM.Antisense-oligonucleotide therapy.N Engl J Med,1996,334(5),316~318
-
2Plenat FN,Klein-Monhoven BM,Vignaud JM.Cell and tissue distribution of synthetic oligonucleotides in healthy and tumor-bearing mice.Am J Pathol,1999,147,124~135
-
3DePinho RA,Schreiber-Agus N,Alt FW.Myc family oncogenes in the development of normal and neoplastic cells.Adv Cancer Res,1991,57,1~46
-
4Nesbit CE,Tersak JM,Prochownik EV.Myc oncogenes and human neoplastic disease.Oncogene,1999,18,3004~3016
-
5Mizutani Y,Bonavida B,Fukumoto M,et al.Enhanced susceptibility of c-myc antisense oligonucleotide-treated human renal cell carcinoma cells to lysis by peripheral blood lymphocytes.J Immunother Emphasis Tumor Immunol,1995,17,78~87
-
6Balaji KC,Koul H,Mitra S.Antiproliferative effects of c-myc antisense oligonucleotide in prostate cancer cells:a novel therapy in prostate cancer.Urology,1997,50,1007~1015
-
7Cho-Chung YS.Antisense oligonucleotide inhibition of serine/threonine kinases:an innovative approach to cancer treatment.Pharmacol Ther,1999,82,437~449
-
8Brown D,Yu ZP,Miller P.Modulation of ras expression by antisense,nonionic deoxyoligonucleotide analogs.Oncogene Res,1989,4,243~252
-
9Saison-Behmoaras T,Tocque B,Rey I.Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation.EMBO J,1991,10,1111~1118
-
10Gordon MS,Sandler AB,Holmlund JT.A phase I trial of ISIS 2503,an antisense inhibitor of H-ras,administered by a 24-hour weekly infusion to patients with advanced cancer.Proc Am Soc Clin Oncol,1999,18,157
-
1莫钦国,梁安民.原发性肝癌以外科为主的综合治疗研究进展[J].广西医学,2004,26(1):58-60. 被引量:7
-
2徐霞,齐翠花,田书信,郑勇,陈卫刚.新疆哈萨克族胃癌主要危险因素的综合分析[J].农垦医学,2013,35(2):152-155.
-
3沈迪,齐军.肺癌早期诊断标志物研究进展[J].标记免疫分析与临床,2013,20(5):336-339. 被引量:12
-
4黄晓燕(摘).VEGF与EGFR联用对晚期结直肠癌无额外获益[J].国外药讯,2008(9):19-20.
-
5刘治坤,叶春祥.不同药物对胃癌细胞株中hTERT表达及胃癌细胞凋亡的影响[J].基层医学论坛,2009,13(22):747-748. 被引量:1
-
6章金强,刘季春.E-钙黏附素基因甲基化及蛋白的表达在食管癌中的研究进展[J].南昌大学学报(医学版),2012,52(1):93-95. 被引量:6
-
7时志龙,张妤,殷正丰.靶向循环肿瘤细胞——防治肝癌术后复发转移的新策略[J].中华肿瘤杂志,2014,36(6):401-404. 被引量:4
-
8刘延军,赵玉霞,张远航.三维适形放射治疗原发性肝癌疗效观察[J].中国肿瘤临床与康复,2006,13(1):78-78.
-
9张涛,高静,王强,顾丽.单克隆抗体治疗肿瘤研究进展[J].包头医学院学报,2005,21(4):428-431. 被引量:1
-
10丁旭贝,郑秋月.乳腺癌多药耐药机制的研究进展[J].医学综述,2014,20(22):4087-4089. 被引量:5