摘要
以 1,4 对醌、芳肼为原料 ,通过Aza Nenitzescu反应、氧化银氧化得到吲唑醌 ,亲核试剂 (各种芳香胺 )在Ce3 + 催化下与吲唑醌发生迈克尔加成反应 ,得到一系列 5 芳氨基基取代的吲唑醌 .化合物结构经元素分析、IR及1HNMR证实 .初步的生理活性研究表明 ,这些化合物具有良好的抗哮喘活性 .
Indazolequinone derivatives have been synthesized by the aza-Nenitzescu reaction of benzoquinones With amenammes-hydrazones, followed by oxidation with Ag2O/celite. The Micheal addition of arylamine to indazolequinone produces novel 5-arylarminoindazolequinone catalyzed by Ce3+. These products were characterized by elemental analyses, IR and H-1 NMR spectra. Preliminary bioassays indicated that these compounds possessed anti-inflammatory activity.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第7期819-821,J005,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金 (Nos.2 0 0 32 0 2 1
2 0 2 72 0 85)
广东自然科学基金 (No.0 2 1 770 )资助项目
