摘要
目的 研究12 5I UdR在胰腺癌裸鼠模型中的分布、治疗效果和用药安全性。方法 胰腺癌裸鼠模型瘤内注射12 5I UdR ,通过SPECT显像和测量各脏器放射性活度来观察12 5I UdR的药物分布规律 ;观察用药后瘤体外观和组织细胞的变化并作生存分析 ;分析用药后外周血象、肝肾功能等指标及骨髓象的表现来评价12 5I UdR的安全性。结果 12 5I UdR局部注射后可在瘤内持续浓聚并致肿瘤细胞坏死 ;接受治疗的荷瘤鼠生存期明显延长 ;其外周血象和肝肾功能无明显变化 ,但骨髓象显示一过性的增生抑制。结论 12 5I UdR可在肿瘤内持续浓聚并使肿瘤细胞坏死 ,有效延长生存期 ,但伴有一过性的骨髓增生抑制。
Objective To investigate the distribution, therapeutic effect and safety of 5-[ 125I]iodo-2′-deoxyuridine( 125I-UdR) in Balb/c nude mice bearing pancreatic cancer. Methods After 125I-UdR was intratumourally injected, the distribution of 125I-UdR was estimated by SPECT scintigrams and the radioactivity of various organs was determined by γ well counter, the antineoplastic capabilities was demonstrated through estimating the gross pathological and cellular changes of tumour, as well as analyzing the survival rate; and the pharmic safety was evaluated by using hemogram, marrow cell and flow biochemistry indexes: alanine aminotransferase(ALT), aspartate aminotransferase(AST),blood urea nitrogen(BUN), creatinine(Cr). Results ⑴ intratumourally injected 125I-UdR was retained within the tumour tissue without serious leakage. ⑵ 125I-UdR could damage cancerous cell and distinctly extended the survival of tumour-bearing mice. ⑶ The changes of hemogram and biochemistry indexes were not observed, but the proliferation of marrow cells was suppressed within a short period (30 d) after intratumoral injection of 125I-UdR. Conclusion 125I-UdR can selectively kill proliferative tumour cells, and distinctly extend the survival of tumour-bearing mice, but the proliferation of marrow cells is suppressed within a short period.
出处
《苏州大学学报（医学版）》
CAS
2004年第3期295-298,共4页
Suzhou University Journal of Medical Science
