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色素上皮源性因子与肿瘤 被引量：3

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摘要 色素上皮源性因子 (Pigmentepithelium derivedfactor ,PEDF)是一种存在于正常组织中的可溶性糖蛋白。它具有营养和保护神经、抑制血管形成、促进肿瘤分化和凋亡等功能。PEDF是近年来国外研究较多的肿瘤生长和转移抑制因子之一 ,它的发现和其对肿瘤作用机制的阐明 ,对于人类恶性肿瘤的基础研究和临床应用具有重要的意义。
作者 方建晨 邵春奎 苏祖兰
机构地区 中山大学第三附属医院病理科
出处 《国外医学（生理病理科学与临床分册）》 2004年第3期283-285,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 广东省自然科学基金 ( 0 0 14 0 7)
关键词 色素上皮源性因子 肿瘤 血管形成
分类号 R730.2 [医药卫生—肿瘤]
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参考文献19

  • 1Simonovic M, Gettins PG, Volz K. Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor[J]. Proc Natl Acad Sci, 2001,98:11131-11135.
  • 2Alberdi E, Aymerich MS, Becerra SP. Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons:evidence for a PEDF receptor [J]. J Biol Chem, 1999, 274(44) :31605-31612.
  • 3Alberdi EM, Weldon JE, Becerra SP. Glycosaminoglycans in human retinoblastoma cells: heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions [ J ]. BMC Biochem, 2003 4 ( 1 ) : 1-9.
  • 4Houenou I3, D'Costa AP, Li L,et al. Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons[J]. J Comp Neurol,1999,412(3) :506-514.
  • 5DeCoster MA, Schabelman E, Tombran-Tink J,et al. Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons [ J 1- J Neurosci Res,1999,56(6) :604-610.
  • 6Ogata N, Wang L, Jo N,et al. Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury [ J 1. Curr Eye Res, 2001,22(4) :245-252.
  • 7Crawford SE, Stellmach V, Ranalli M,et al. Pigment epithelium-derived factor (PEDF) in neuroblastoma: a muhifunctional mediator of Schwann cell antitumor activity [ J ]. J Cell Sci,2001 , 114 ( 24 ) :4421-4428.
  • 8Yabe T, Wilson D, Schwartz JP. NFkappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons[ J]. J Biol Chem,2001,276(46) :43313-43319.
  • 9Araki T, Taniwaki T, Becerra SP,et al. Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death [ J 1. J Neurosci Res, 1998,53( 1 ) :7-15.
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同被引文献23

  • 1Stoeltzing O, Ellis LM. Regulation of vascular endothelial growth factor expression in cancer [ J]. Cancer Treat Res,2004 (11 ) :33-582.
  • 2丁道芳,谢启文,刘述舜.医学科学研究基本方法法[M].大连:辽宁科学技术出版社,1998:261-261.
  • 3Mori A,Arii S,Furutani M,et al. Vascular endothdial growth factor induced tumor angiogenesis and tumorigenicity in relation to metastasis in a 1080 human fibrosarcoma cell model [J]. Int Cancer,1999, 80(5 ) :738-739.
  • 4Holash J, Maisopiene PC, Compton D, et al, Vessel cooperation, regression and growth in tumors mediated by giopoietlns and VEGF [J]. Science, 1999,24(22) : 1994-1998.
  • 5Volper TOV,Zaiehuk T,Zhou W,et al. Indueed stimulated Fas targets aetived endothelial for destruetion by anti-angiogenie thrombospondin-land pigment epithelium derived factor [ J ]. Nat Meal, 2002,8(4) :349-357.
  • 6Wang L, Schmitz V, Perez-mediavilla A, et al. Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor[ J]. Mol ther,2003,8( 1 ) :72-79.
  • 7DOLL J A,STELLMACH V M,BOUCK N P,et al.Pigment epithelium -derived factor regulates the vasculature and mass of the prostate and pancreas[J].Nat Med,2003,9(6):774-780.
  • 8CRAWFORD S E,STELLMACH V,RANALLI M,et al.Pigment epithelium-derived factor (PEDF) in neuroblastoma:a multffunctional mediator of Schwann cell antitumor activity[J].J Cell Sci,2001,114(24):4421-4428.
  • 9GUAN M,YAM H F,SU B,et al.Loss of pigment epithelium derived factor expression in glioma progression[J].J Clin Pathol,2003,56(4):277-282.
  • 10QUAN G M,OJAIMI J,NADESAPILLAI A P,et al.Resistance of epiphyseal cartilage to invasion by osteosarcoma is likely to be due to expression of antiangiogenic factors[J].Pathobiology,2003,70(6):361-367.

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国外医学（生理病理科学与临床分册）
2004年 第3期

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