摘要
目的 :探讨肝硬化患者血清一氧化氮 (NO)对食管动力及食管静脉曲张破裂出血 (EVB)的影响。方法 :本文采用核素扫描法测定 4 2例肝硬化食管静脉曲张患者 (EV)和 30例健康人 (HS)食管液体通过时间和胃食管反流 ,硝酸还原酶法测定血清NO含量 ;并随访 1年。结果 :EV组血浆NO含量显著高于HS组 (P <0 .0 5 ) ;EV组胃食管反流发生率显著高于HS组 (P<0 .0 5 ) ;EV组中胃食管反流患者的NO含量显著高于无胃食管反流的患者 (P <0 .0 5 ) ,EV食管动力异常组血清NO含量显著高于EV食管动力正常组 (P <0 .0 5 ) ;EV食管动力异常组出血率显著高于EV食管动力正常组 (P <0 .0 5 )。结论 :肝硬化患者血清NO含量的升高可能使食管下段括约肌 (LES)松弛而产生胃食管反流 ,进而导致EVB机会增加。
Objective: To study the relationship among serum nitric oxide (NO) esophageal motility and cirrhotic patients with esophageal varices bleed (EVB). Methods: Esophageal liquid transit time and gastroesophageal reflux(GER) with scintigraphy were detected in 42 cirrhotic patients with esophageal varices(EV) and 30 healthy subjects(HS)and serum NO concentration with colorimetric assay ;one year follow-up. Results: Serum NO concentration were significant difference between EV group and HS group(P<0.05);the frequency of gastroesophageal reflux in EV group was markedly higher than that in HS group(P<0.05);there were also significant difference between patients without GER and with GER in serum NO concentration(P<0.05);Bleeding rate were significant difference between GER-positive of cirrhotic patients with EV group and GER-negative group(P<0.05). Conclusion:Serum levels of Nitric Oxide may make low esophageal sphincter relax, and cause GER and EVB.
出处
《中国临床医学》
2004年第3期348-349,共2页
Chinese Journal of Clinical Medicine
