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己酮可可碱在脓毒症中的作用和机制 被引量：1

Effects and mechanisms of pentoxifylline in sepsis
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摘要 脓毒症可促使宿主发生复杂炎症的病理生理改变。己酮可可碱 (Pentoxifylline ,PTX)是甲基黄嘌呤的衍生物 ,具有选择性抗炎作用。作者阐述了PTX在脓毒症中作用和机制的实验研究和临床试验 ,为脓毒症的治疗提供新的思路。 It is increasingly evident that sepsis triggers a complex host reaction, which is responsible for a variety of pathophysiologic changes during the inflammatory process. Pentoxifylline (PTX) is a methyxanthine with selective anti inflammatory activity. The effects and mechanisms of PTX in human and animal models of sepsis are reviewed, for providing new information in treatment of sepsis.
作者 王莉琴 徐建国
机构地区 南京军区南京总医院麻醉科
出处 《医学研究生学报》 CAS 2004年第7期661-663,共3页 Journal of Medical Postgraduates
关键词 己酮可可碱 脓毒症 抗炎作用 Pentoxifylline Sepsis Anti imflammatory
分类号 R631 [医药卫生—外科学]
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参考文献21

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同被引文献14

  • 1嵇晴,杨建军,孙杰,徐建国.氯胺酮抑制内毒素诱导的核因子-κB及肿瘤坏死因子α的体内研究[J].医学研究生学报,2005,18(4):334-337. 被引量：10
  • 2陈海妮,姜会庆,胡心宝,刘坤,解伟光,汪涌,汪军.内毒素预处理对单个核细胞分泌肿瘤坏死因子α和诱生型一氧化氮合酶及NO的影响[J].医学研究生学报,2006,19(9):774-776. 被引量：4
  • 3Riedemann NC, Guo RF, Ward PA. The enigma of sepsis [J]. J Clin Invest, 2003, 112 (4) :460-467.
  • 4Riedemann NC, Guo RF, Ward PA. Novel strategies for the treatment of sepsis [J]. Nat Med, 2003, 9(5) :517-524.
  • 5Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock [ J]. N Engl J Med, 2001, 345(19) :1368-1377.
  • 6van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients [ J ]. N Engl J Med, 2001, 345(19) :1359-1367.
  • 7Tian J, Lin X, Guan R, et al. The effects of hydroxyethyl starch on lung capillary permeability in endotoxic rats and possible mechanisms [J]. Anesth Analg, 2004, 98(3);768-774.
  • 8Tian J, Lin X, Zhou W, et al. Hydroxyethyl starch inhibits NF- kappaB activation and prevents the expression of inflammatory mediators in endotoxic rats [ J]. Ann Clin Lab Sci, 2003, 33 (4) :451-458.
  • 9Feng X, Yan W, Liu X, et al. Effects of hydroxyethyl starch 130/0.4 on pulmonary capillary leakage and cytokines production and NF-kappaB activation in CLP-induced sepsis in rats [ J ]. J Surg Res, 2006, 135(1) :129-136.
  • 10Bernard GR, Vincent JL, Laterre PF, et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis [J]. N Engl J Med, 2001,344(10) : 699-709.

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医学研究生学报
2004年 第7期

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