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EB病毒感染相关的噬血细胞性淋巴组织细胞增生症的临床特征和治疗策略 被引量：4

Clinical features and therapeutic strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
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摘要 EB病毒感染相关的噬血细胞性淋巴组织细胞增生症 (EBV HLH)好发于免疫缺陷的儿童和青少年 ,常呈暴发性经过 ,预后不良。由EBV感染的T/NK细胞大多呈单 或寡 克隆增殖。高细胞因子血症是本病发病的重要中间机制。抑制或清除含EBV基因组的T/NK细胞增殖 ,并积极控制细胞因子暴是本病治疗的关键。 The majority cases of Epstein Barr virus associated hemophagocytic lymphohistiocytosis (EBV HLH) are apparently immunocompetent children and adolescents. The clinical courses are often fulminant and the poor outcome is usually. In patients with EBV HLH, the EBV infected T cells or natural killer (NK) cells are mostly mono or oligo clonally proliferating. Where hypercytokinemia plays a major pathogenetic middle mechanism. To reduce or eradicate proliferation of EBV infected T/NK cells, and aggressively control the cytokine storm generated by T/NK cells containing EBV genome are the special therapeutic measures for this disease.
作者 王学文
机构地区 南京军区南京南京总医院血液科
出处 《医学研究生学报》 CAS 2004年第7期637-640,共4页 Journal of Medical Postgraduates
关键词 EB病毒 噬血细胞性 淋巴组织细胞增生症 临床特征 治疗 Epstein-Barr virus Hemophagocytic Lymphohistiocytosis Clinical features Treatment
分类号 R557.4 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献26

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二级参考文献23

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共引文献41

同被引文献61

引证文献4

二级引证文献19

医学研究生学报
2004年 第7期

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