摘要
目的使用健康状况调查问卷简表-36(SF-36)量表评价系统性红斑狼疮(SLE)患者的生存质量(QOL)及其影响因素。方法选择不同病情的SLE患者151例进行SF-36量表调查问卷,分析量表各维度得分与疾病活动性指数(SLEDAI)、损伤指数(SLICC/ACRDI)、治疗方案等因素相关性。结果SLE患者SF-36量表各维度得分和健康变化自评(HT)低于中国常模,部分维度得分高于国外SLE患者;活动期、合并肾、脑内脏损伤的患者QOL得分低于非活动期、无肾脑损伤者。影响QOL最主要的因素是SLEDAI和DI记分并呈明显负相关;QOL还受激素使用剂量、年龄、病程、文化程度等因素的影响。结论SF-36量表适于评价SLE患者的QOL,患者的QOL受病情活动度、严重性及治疗方案的影响。
Objective To determine health related quality of life (QOL) of patients with systemic lupus erythematosus (SLE) and to identify the factors affecting QOL. Methods One hundred and fifty-one consecutive patients with SLE were separated into different groups according to the type or stage of disease. Health status were measured by 1 health transition (HT) and 8 composite scales of the medical outcomes study short form-36 (SF-36). The mean scores for each subscale of the SF-36 for patients with SLE in China were compared to those of a health population in China and of foreign SLE patients.The effect of patients′age,sex,education level,disease duration,disease activity (assessed by SLEDAI score),and organ damage(assessed by SLICC/ACR DI) and treatment were analyzed. ANOVA, rank sum test and correlation analysis were applied for statistical analysis. Results Patients with SLE had significantly lower HT and mean scores in each subscale of the SF-36 compared to those of a health population in China,while the scores in such subscales as physical functioning (PF), bodily pain (BP), vitality (VT), role-emotional (RE) and mental health (MH) were higher than those of foreign SLE patients. The mean scores of those patients with lupus nephritis and center neural lupus or in active state were lower than those not or those in steady-going. The SLEDAI score and SLICC/ACR DI were the most important elements that affected the QOL in SLE patients and showed obviously negative correlated with one′s scores in SF-36. The glucocorticoid dose of patients was closely negatively correlated with one′s scores. The latter were also associated with age, education level and disease duration. Conclusion The health status of patients with SLE is mainly associated with disease activity,damage and therapy. The SF-36 is a valid instrument for measuring the health related QOL in SLE.
出处
《中华风湿病学杂志》
CAS
CSCD
2004年第7期420-423,共4页
Chinese Journal of Rheumatology
关键词
系统性红斑狼疮
生存质量
影响因素
调查
诊断
临床分期
Lupus erythematosus, systemic
Medical outcomes study short form-36
Quality of life
