摘要
目的 探讨氯氮平对精神分裂症患者脂质代谢的影响。方法 采用自身对照方法 ,比较 4 5例精神分裂症患者在氯氮平治疗前和治疗后第 8周末的血脂水平变化。结果 氯氮平治疗后患者的TG水平明显升高 (P <0 0 1) ,而HDL则明显降低 (P <0 0 5 ) ;治疗后男性的HDL水平明显降低 (P <0 0 5 ) ;女性的TG水平则明显升高 (P<0 0 1) ;氯氮平剂量与血清TG水平呈正相关 (P <0 0 1) ,与血清HDL水平无明显相关 (P >0 0 5 ) ;治疗后心电图出现异常者的TG水平明显高于无异常组者 (P <0 0 5 )。在治疗第 8周末体重增加与血清高TG和低HDL水平均无明显相关性 ((P >0 0 5 )。结论 氯氮平治疗可引起血脂异常 。
Objective To study the effects of clozapine on lipometabolism in schizophrenic patients.Methods Using self-control method,blood-lipid levels were measured at the baseline and the end 8 weeks in 45 schizophrenic patients treated with clozapine.Results After clozapine treatment TG levels were increased significantly(P<0.01),and HDL levels decreased(P<0.05);HDL levels in male patients low(P<0.05).The dosage of clozapine and positive correlation with plasma TG(P<0.01),and had no correlation with HDL levels, TG levels in patients with abnormal ECG (electrocardiogram) were higher than with normal ECG.Weight gain had no correlation with plasma TG and HDL(P>0.05).Conclusion Clozapine treatment may cause abnormal blood-lipid level and then myocardial damage,but no weight gain in short term.
出处
《四川精神卫生》
2004年第3期156-157,共2页
Sichuan Mental Health
