摘要
目的 :探讨婴儿巨细胞病毒 (cytomegalovirus,CMV)感染的临床特点、检测手段及治疗。方法 :对 2 5例经酶免疫斑点技术确诊为CMV感染的婴儿的临床资料进行分析。结果 :支气管肺炎 11例 (4 4 % ) ,中枢神经系统损害 11例 (4 4 % ) ,高胆红素血症 8例 (32 % ) ,所有病例均给予更昔洛韦 (ganciclovir ,GCV)治疗 ,支气管肺炎治愈 8例 ,好转 3例 ;中枢神经系统损害治愈1例 ,好转 9例 ,未愈 1例 ;高胆红素血症治愈 2例 ,好转 6例。结论 :婴儿CMV感染以支气管肺炎、中枢神经系统损害和高胆红素血症为多见 ,血清特异性CMV IgM抗体阳性为CMV感染的实验室诊断依据 ,GCV是治疗婴儿CMV感染的首选药物。
Objective:To explore the clinical features of infants infected with cytomegalovirus(CMV) and investigate the detection methods and treatment.Methods:The clinical data of 25 infants with CMV infection confirmed by detection of serum CMV-IgM using enzyme immunodot technic were analyzed.Results:Of the 25 patients,bronchopneumonia accounted for 11 cases(44%),central nervous system damage 11 cases(44%)and hyperbilirubinemia 8 cases(32%).All the patients were treated with ganciclovir.Bronchopneumonia was cured in 8 cases and improved in 3 cases.Central nervous system damage was cured in 1 case,improved in (9 cases) and uncured in 1 case.Hyperbilirubinemia was cured in 2 cases and improved in 6 cases.Conclusions:The most common manifestations of CMV infection in infants include bronchopneumonia,central nerves system damage and hyperbilirubinemia.The presence of serum CMV-IgM antibody is a laboratory diagnostic evidence.Ganciclovir is the choice of treatment for CMV infection.
出处
《蚌埠医学院学报》
CAS
2004年第4期304-306,共3页
Journal of Bengbu Medical College
关键词
巨细胞病毒
感染
婴儿
更昔洛韦
cytomegalovirus
infection
infant
ganciclovir
