摘要
目的 探讨重组人生长激素 (rhGH)对危重病患者脏器功能不全的治疗干预作用。方法 将 38例多脏器功能衰竭常规应用抗生素、营养支持治疗的患者 ,随机分为rhGH组和对照组 ,rhGH组皮下注射rhGH 5U ,连用 2周。结果 rhGH组于治疗后第 7天起 ,患者的APACHEⅡ评分明显降低 ,ALT、AST、BUN及Cre与对照组相比差异无显著性意义 ,而血清白蛋白有所增加 ,差异有显著性意义 (P<0 .0 5 )。rhGH组与对照组相比 ,其入住ICU时间、机械通气时间及住院时间均明显减少 ,差异有显著性意义 (P<0 .0 5 )。结论 应用rhGH可以改善危重症患者的病理生理状态而对肝、肾功能无明显影响 ,同时可缩短住院时间 。
Objective To investigate the role of recombinant human growth hormone (rhGH) in the treatment of patients with multiple organ dysfunction syndrome (MODS). Methods Thirty eight patients with MODS routinely treated with antibiotics and nutrition support were divided into two groups: the rhGH group and control group. The rhGH group was treated by subcutaneous injection of 5 U rhGH for two weeks. Results On the 7th day of treatment, the score of APACHE Ⅱ in the rhGH group was much higher than the control group, the levels of ALT, AST, BUN and Cre did not change much compared with the control group. The level of albumin in the rhGH group increased ( P <0.05). The stay in ICU, time of mechanical ventilation and hospital stay decreased compared with the control group ( P <0.05). Conclusion rhGH can effectively improve the pathophysiology of critically ill patients and has no side effects on the function of liver and kidney, meanwhile it can shorten hospital stay and decrease mortality.
出处
《中国普外基础与临床杂志》
CAS
2004年第4期344-346,共3页
Chinese Journal of Bases and Clinics In General Surgery
