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凋亡抑制蛋白XIAP的研究进展 被引量：2

Advances in the Research of Inhibitor-of-Apoptosis Protein XIAP
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摘要 XIAP是IAP家族中抑制细胞凋亡的最主要成员,本文总结了近年来对XIAP结构与功能的研究进展,基本明确了XIAP与caspase3、7、9的作用方式及其自身的调节方式,探讨了XIAP的抗凋亡机制,及其信号分子作用和在凋亡相关疾病中潜在的治疗价值。 XIAP is the most important member of IAP family. This article reviews the recent advances in the research of this molecule, including its structure and function, interaction with caspase3 , 7 or 9, the regulation models and the mechanism of apoptosis inhibition. Moreover, its potential value in the therapy of apoptosis-associated diseases is also discussed.
作者 李庆霞 杨安钢
机构地区 第四军医大学生物化学与分子生物学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2004年第2期113-115,共3页 Journal of Medical Molecular Biology
基金 国家杰出青年科学基金(39925036)
关键词 XIAP 细胞凋亡 基因治疗 XIAP apoptosis gene-therapy
分类号 Q7 [生物学—分子生物学]
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参考文献17

  • 1Holcik M,Gordon BW,Korneluk RG.The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.Mol Cell Biol,2003,23(1):280-88.
  • 2Miranda MB,Dyer KF,Grandis JR,et al.Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation:a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells.Leukemia,2003,17(2):390-400.
  • 3Bilim V,Kasahara T,Hara N,et al.Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro.Int J Cancer,2003,103(1):29-37.
  • 4Shiozaki EN,Chai J,Rigotti DJ,et al.Mechanism of XIAP-Mediated Inhibition of Caspase-9.Mol Cell,2003,11(2):519-27.
  • 5Holcik M,Korneluk RG.XIAP,the guardian angel.Nat Rev Mol Cell Bio,2001,2(7):550-6.
  • 6Srinivasula SM,Hegde R,Saleh A,et al.A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.Nature,2001,410:112-6.
  • 7Hofer WR,Schmid JA,Stehlik C,et al.Activation of NF-kappa B by XIAP,the X chromosome-linked inhibitor of apoptosis,in endothelial cells involves TAK1.J Biol Chem,2000,275(29):22 064-8.
  • 8Nomura T,Mimata H,Takeuchi Y,et al.The X-linked inhibitor of apoptosis protein inhibits taxol-induced apoptosis in LNCaP cells.Urol Res,2003,31(1):37-44.
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同被引文献18

  • 1张正中,张学军,杨森,眭维耻.银屑病与细胞凋亡[J].国际皮肤性病学杂志,2006,32(3):179-181. 被引量：3
  • 2Liu M J,Liu M L,Shen Y F,et al.Transgenic mice with neuronspe-cific overexpre ssion of HtrA2/Omi suggest a neuroprotective role for HtrA2/Omi.Biochem Biophys Res Commun 2007;362(2):295-300.
  • 3Hao XP,Willis JE,Pretlow TG,et al.Loss offragile histidine triad expression in colorectalcarcinom as and prem alignantlesions.Cancer Res 2000;60(1):18-21.
  • 4Verhagen AM,Silke J,EkertPG,et al.HtrA2 promotes celldeath through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.J Biol Chem 2002;277(1):445-454.
  • 5Huang Y,Park YC,Rich RL,et al.Structuralbasis of caspase in-hibition by XIAP:differential roles of the linker versus the BIR domain.Cell 2001;104(5):781-790.
  • 6Takahashi H,Manabe A,Ishida YA,et al.Aberrant expression of apoptosis-related molecules in psoriatic epidermis.Dermatol Sci 2002;28(3):187-197.
  • 7Shi Y H, Ding W X, Zhou J, et al. Expression of X-linked inhibitor- of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence[J].Hepatology, 2008, 48 ( 2 ) : 497-507.
  • 8Won S H, Lee H J, Jeong S J, et al.Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway[J].Biol Pharm Bull, 2010, 33 ( 11 ) : 1828-1834.
  • 9Holeik M, Korneluk R G.XIAP, the guardian angel[J].Nat Rev Mol Cell Bio, 2001, 2 ( 7 ) : 550-556.
  • 10Huang Y, Park Y C, Rich R L, et al.Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain[J].Cell, 2001, 104 (5) : 781-790.

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医学分子生物学杂志
2004年 第2期

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