摘要
目的 :研究白细胞介素 - 1(IL - 1)在犬颌面部火器伤间接损伤牙髓中的表达情况。方法 :采用直径 (d) 5 .80mm制式枪弹致伤犬下颌部的模型 ,利用免疫组化染色及定量分析方法检测颌面部火器伤后不同时间、下颌不同牙齿的牙髓组织中IL - 1的动态变化。结果 :IL - 1在伤后牙髓组织中有阳性表达 ,并随时间的改变 ,呈动态变化过程。伤侧高于对侧。结论 :IL - 1在颌面部火器伤牙髓间接损伤过程中起重要作用。
AIM:To provide theoretical basis and experimental evidence for diagnosis and therapy of indirect injuries of dental pulp in gunshot wounds.METHODS:The levels of IL-1 in different stages were studied using immunohistochemical method to evaluate its functions in inflammatory process of dental pulps.RESULTS:IL-1 expression was detected by immunohistochemical assay in postwound conditions.The results showed that positive staining of IL-1 was observed predominantly on infiltrating inflammatory cells,vasculars endothelial cells and some fibroblasts,which was consistent to the recruitment and activation of inflammatory cells,and with the severity duration of pulpal tissue injury and response.CONCLUSION:These results indicate that the IL-1 is involved in regulating physiologic responses of dental pulp injuries in maxillofacial trauma by a projectile.
出处
《牙体牙髓牙周病学杂志》
CAS
2004年第6期312-314,共3页
Chinese Journal of Conservative Dentistry
