摘要
目的 探讨超抗原金黄色葡萄球菌肠毒素 (SEA)对体内肿瘤的抑瘤效果及作用机制。方法 采用人胃癌细胞 (MGC80 3 )皮下接种建立小鼠胃癌模型 (n =40 ) ,实验组 (n =2 0 )注射SEA ,对照组 (n =2 0 )注射生理盐水 ,观察肿瘤的发生率及肿瘤的重量。并对瘤体组织应用免疫组织化学方法初步探讨其发生机制。结果 超抗原SEA处理的小鼠肿瘤的发生率低于对照组 ,两者差异无显著性 ;超抗原SEA处理的小鼠肿瘤的重量明显低于对照组 ,两者差异有显著性 (P <0 .0 1) ;SEA处理的小鼠肿瘤组织有CD4+ T细胞和CD8+ T细胞浸润 ,而对照组很少或没有T细胞浸润。结论 超抗原SEA对小鼠胃癌细胞有明显抑瘤效果 。
Objective To invest the anti tumor effect and mechanism of the staphylococcal enterotoxin A(SEA).Methods The subcutaneous tumor model ( n =40) was produced by inplating gastric tumor cell(MGC80 3).The experiment group ( n = 20) was treated with SEA,and the control group ( n = 20) was treated with normal saline.Result The percentage of the tumor generation and tumor weight was lower in the experiment group than that of the control group.The tumor weight has obvious difference between the two groups.There were more CD 4 +T cells and CD 8 +T cells in the tumor of the experiment group than that of the control group.Conclusion The SEA has an obvious anti tumor effect in mice gastric tumor.The SEA induces the effect of superantigen dependent cell mediated cytotoxicity to the tumor cells.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2004年第6期688-689,共2页
Chinese Journal of Experimental Surgery
