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Parkin基因和帕金森病 被引量：2

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摘要 帕金森病(PD)是一种缓慢进展的神经系统变性疾病,Parkin基因突变与早发性PD有关。Parkin主要位于神经元胞浆和突触中,与突触传递有关,其作为泛素连接酶E3参与泛素-蛋白水解酶系统的蛋白降解过程。后者的功能是清除受不良环境影响或细胞内应激状态而形成的错误折叠的蛋白,维持细胞内稳态。Parkin突变使细胞内蛋白代谢紊乱,异常蛋白选择性地聚集于黑质多巴胺能神经元,防碍了多巴胺递质释放和运输,产生帕金森病的症状,同时产生细胞毒性,导致细胞死亡。
作者 洪雁 张本恕 马温良
机构地区 天津市环湖医院神经内科 天津医科大学总医院神经内科
出处 《国外医学（神经病学．神经外科学分册）》 2004年第3期283-286,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 PARKIN基因 帕金森病 PD 神经系统
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献22

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同被引文献17

  • 1张振涛,曹学兵,孙圣刚.帕金森病多巴胺神经元死亡的分子机制[J].中国康复,2006,21(6):402-404. 被引量：17
  • 2CHUNGSJ, ARMASUSM, BIERNACKAJM, et al. Common variantsin PARK loci and related genes and Parkinson’s disease [ J ]. MovDisord, 2011, 26(2): 280-288.
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  • 8SHIMURA H, HATTORI N,KUBO S,et al. Familial Parkinsondisease gene product, parkin, is a ubiquitin-protein ligase [ J ]. NatGenet, 2000,25(3): 302-305.
  • 9金泰虡.现代毒理学[M].上海:复旦大学出版社,2004:18-20.
  • 10Bi-Yin Cao,Ya-Ping Yang,Wei-Feng Luo,Cheng-Jie Mao,Rong Han,Xue Sun,Jing Cheng,Chun-Feng Liu.Paeoniflorin, a potent natural compound, protects PC12 cells from MPP + and acidic damage via autophagic pathway[J].Journal of Ethnopharmacology.2010(1)

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国外医学（神经病学．神经外科学分册）
2004年 第3期

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