摘要
目的 探讨低出生体重儿生后肾上腺皮质功能的变化及临床意义。方法 应用放免的方法对110名低出生体重儿生后1、7、14、21天血清皮质醇水平检测,并与30名足月儿生后相同时段皮质醇水平进行对照。结果 低出生体重儿生后血清皮质醇水平均呈不同程度的下降趋势:足月小样儿、大胎龄早产儿于生后1周达稳态,小胎龄早产儿于生后2周达稳态,达稳态时均与同日龄足月儿水平均值相比差异无显著性。结论 低出生体重儿生后因宫内外环境的变化而产生应激反应使血清皮质醇处于高水平,随生后日龄增加对宫外环境的适应,应激反应减轻,其血清皮质醇水平逐渐下降,最迟于生后2周达稳态,与足月儿水平相比差异无显著性。
Studying the variable changes and clinical significiance of the adrenal function in low
birth weight infant(LBWI). Methods We detected the cordisol levels by radilommunoassay in 177 low
birth weight infants on the 1st. 7th. 14th and 21th day(21 day only for YPI)after birth, and a compara-
tive analysis was done with normal term infant controls (All were appropriate for gestational age infant).
Results Serum levels of cordisol in LBWI elevated at first and then decreased respectively. The normal
term infants with small weight (NTISW) and older preterm infants(OPI, G≥34W) remained stable on
the 1st week after birth. Younger preterm infants(YPI, G<34W) did so on the 2nd postnatal week, but
without significant statistical difference from compared with normal term infants at same time. Conclu-
sions LBWI would make active react after birth to the variaty from intrauterine life to postnetal life.
Their cordisol levels will get to a stable level at 2 weeks of age, and they are compariable with those of
full term infant.
出处
《新生儿科杂志》
CAS
2004年第3期106-108,144,共4页
The Journal of Neonatology
基金
吉林省科学技术委员会基金资助项目(项目编号
吉科合字第19990317-02号)
